Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM145713
(US8952177, 67 | US9089569, 67 | US9695149, 67)Show SMILES Cc1ccc(COc2cc(F)c3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)nc1 |r| Show InChI InChI=1S/C29H27F4N3O4/c1-17-6-9-19(34-14-17)16-39-21-12-24(30)26-25(13-21)36(15-18-7-10-20(11-8-18)40-29(31,32)33)27(35-26)22-4-2-3-5-23(22)28(37)38/h6-14,22-23H,2-5,15-16H2,1H3,(H,37,38)/t22?,23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in... |
US Patent US8952177 (2015)
BindingDB Entry DOI: 10.7270/Q2G73CFW |
More data for this
Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM145713
(US8952177, 67 | US9089569, 67 | US9695149, 67)Show SMILES Cc1ccc(COc2cc(F)c3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)nc1 |r| Show InChI InChI=1S/C29H27F4N3O4/c1-17-6-9-19(34-14-17)16-39-21-12-24(30)26-25(13-21)36(15-18-7-10-20(11-8-18)40-29(31,32)33)27(35-26)22-4-2-3-5-23(22)28(37)38/h6-14,22-23H,2-5,15-16H2,1H3,(H,37,38)/t22?,23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9695149 (2017)
BindingDB Entry DOI: 10.7270/Q2Q52MSC |
More data for this
Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM145713
(US8952177, 67 | US9089569, 67 | US9695149, 67)Show SMILES Cc1ccc(COc2cc(F)c3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)nc1 |r| Show InChI InChI=1S/C29H27F4N3O4/c1-17-6-9-19(34-14-17)16-39-21-12-24(30)26-25(13-21)36(15-18-7-10-20(11-8-18)40-29(31,32)33)27(35-26)22-4-2-3-5-23(22)28(37)38/h6-14,22-23H,2-5,15-16H2,1H3,(H,37,38)/t22?,23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9089569 (2015)
BindingDB Entry DOI: 10.7270/Q23X85DB |
More data for this
Ligand-Target Pair | |