Found 6 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Alpha-1D adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50143717
(8-{2-[4-(2-Chloro-5-methyl-phenyl)-piperazin-1-yl]...)Show SMILES Cc1ccc(Cl)c(c1)N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 Show InChI InChI=1S/C22H30ClN3O2/c1-17-4-5-18(23)19(14-17)25-11-8-24(9-12-25)10-13-26-20(27)15-22(16-21(26)28)6-2-3-7-22/h4-5,14H,2-3,6-13,15-16H2,1H3 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.91 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati s.p.a.
Curated by ChEMBL
| Assay Description
Binding affinity to the adrenergic receptor alpha-1D of rat aorta |
J Med Chem 47: 1900-18 (2004)
Article DOI: 10.1021/jm030944+
BindingDB Entry DOI: 10.7270/Q23F4P35 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50143717
(8-{2-[4-(2-Chloro-5-methyl-phenyl)-piperazin-1-yl]...)Show SMILES Cc1ccc(Cl)c(c1)N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 Show InChI InChI=1S/C22H30ClN3O2/c1-17-4-5-18(23)19(14-17)25-11-8-24(9-12-25)10-13-26-20(27)15-22(16-21(26)28)6-2-3-7-22/h4-5,14H,2-3,6-13,15-16H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 69.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati s.p.a.
Curated by ChEMBL
| Assay Description
Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]-8-OH-DPAT) as radioli... |
J Med Chem 47: 1900-18 (2004)
Article DOI: 10.1021/jm030944+
BindingDB Entry DOI: 10.7270/Q23F4P35 |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50143717
(8-{2-[4-(2-Chloro-5-methyl-phenyl)-piperazin-1-yl]...)Show SMILES Cc1ccc(Cl)c(c1)N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 Show InChI InChI=1S/C22H30ClN3O2/c1-17-4-5-18(23)19(14-17)25-11-8-24(9-12-25)10-13-26-20(27)15-22(16-21(26)28)6-2-3-7-22/h4-5,14H,2-3,6-13,15-16H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to adrenergic alpha1A receptor (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-010-9379-1
BindingDB Entry DOI: 10.7270/Q2NG4THH |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50143717
(8-{2-[4-(2-Chloro-5-methyl-phenyl)-piperazin-1-yl]...)Show SMILES Cc1ccc(Cl)c(c1)N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 Show InChI InChI=1S/C22H30ClN3O2/c1-17-4-5-18(23)19(14-17)25-11-8-24(9-12-25)10-13-26-20(27)15-22(16-21(26)28)6-2-3-7-22/h4-5,14H,2-3,6-13,15-16H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to adrenergic alpha1A receptor (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-010-9379-1
BindingDB Entry DOI: 10.7270/Q2NG4THH |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50143717
(8-{2-[4-(2-Chloro-5-methyl-phenyl)-piperazin-1-yl]...)Show SMILES Cc1ccc(Cl)c(c1)N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 Show InChI InChI=1S/C22H30ClN3O2/c1-17-4-5-18(23)19(14-17)25-11-8-24(9-12-25)10-13-26-20(27)15-22(16-21(26)28)6-2-3-7-22/h4-5,14H,2-3,6-13,15-16H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati s.p.a.
Curated by ChEMBL
| Assay Description
In vitro binding affinity towards alpha-1A adrenergic receptor through displacement of [3H]-prazosin in epididymal rat vas deferens. |
J Med Chem 47: 1900-18 (2004)
Article DOI: 10.1021/jm030944+
BindingDB Entry DOI: 10.7270/Q23F4P35 |
More data for this
Ligand-Target Pair | |
Alpha-1B adrenergic receptor
(Homo sapiens (Human)) | BDBM50143717
(8-{2-[4-(2-Chloro-5-methyl-phenyl)-piperazin-1-yl]...)Show SMILES Cc1ccc(Cl)c(c1)N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 Show InChI InChI=1S/C22H30ClN3O2/c1-17-4-5-18(23)19(14-17)25-11-8-24(9-12-25)10-13-26-20(27)15-22(16-21(26)28)6-2-3-7-22/h4-5,14H,2-3,6-13,15-16H2,1H3 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 193 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati s.p.a.
Curated by ChEMBL
| Assay Description
Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleen |
J Med Chem 47: 1900-18 (2004)
Article DOI: 10.1021/jm030944+
BindingDB Entry DOI: 10.7270/Q23F4P35 |
More data for this
Ligand-Target Pair | |