Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM145743
(US8952177, 97 | US9089569, 97 | US9695149, 97)Show SMILES Cc1ccc(Cn2c(nc3c(F)cc(OCc4ccn(C)n4)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1 |r| Show InChI InChI=1S/C27H29FN4O3/c1-17-7-9-18(10-8-17)15-32-24-14-20(35-16-19-11-12-31(2)30-19)13-23(28)25(24)29-26(32)21-5-3-4-6-22(21)27(33)34/h7-14,21-22H,3-6,15-16H2,1-2H3,(H,33,34)/t21-,22+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in... |
US Patent US8952177 (2015)
BindingDB Entry DOI: 10.7270/Q2G73CFW |
More data for this
Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM145743
(US8952177, 97 | US9089569, 97 | US9695149, 97)Show SMILES Cc1ccc(Cn2c(nc3c(F)cc(OCc4ccn(C)n4)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1 |r| Show InChI InChI=1S/C27H29FN4O3/c1-17-7-9-18(10-8-17)15-32-24-14-20(35-16-19-11-12-31(2)30-19)13-23(28)25(24)29-26(32)21-5-3-4-6-22(21)27(33)34/h7-14,21-22H,3-6,15-16H2,1-2H3,(H,33,34)/t21-,22+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9695149 (2017)
BindingDB Entry DOI: 10.7270/Q2Q52MSC |
More data for this
Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM145743
(US8952177, 97 | US9089569, 97 | US9695149, 97)Show SMILES Cc1ccc(Cn2c(nc3c(F)cc(OCc4ccn(C)n4)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1 |r| Show InChI InChI=1S/C27H29FN4O3/c1-17-7-9-18(10-8-17)15-32-24-14-20(35-16-19-11-12-31(2)30-19)13-23(28)25(24)29-26(32)21-5-3-4-6-22(21)27(33)34/h7-14,21-22H,3-6,15-16H2,1-2H3,(H,33,34)/t21-,22+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9089569 (2015)
BindingDB Entry DOI: 10.7270/Q23X85DB |
More data for this
Ligand-Target Pair | |