Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Voltage-dependent T-type calcium channel subunit alpha-1H
(Homo sapiens (Human)) | BDBM50192737
(CHEMBL3910259)Show SMILES Cc1ccc(cc1)C1(CCO)CC(=NN1C(=O)Nc1ccc(F)cc1)c1ccncc1 |c:13| Show InChI InChI=1S/C24H23FN4O2/c1-17-2-4-19(5-3-17)24(12-15-30)16-22(18-10-13-26-14-11-18)28-29(24)23(31)27-21-8-6-20(25)7-9-21/h2-11,13-14,30H,12,15-16H2,1H3,(H,27,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human T-type calcium channel Cav3.2 expressed in CHO cells assessed as inhibition of calcium tail current at -90 mV holding potential m... |
J Med Chem 59: 8398-411 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00756 BindingDB Entry DOI: 10.7270/Q2J67JWK |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1C
(Homo sapiens (Human)) | BDBM50192737
(CHEMBL3910259)Show SMILES Cc1ccc(cc1)C1(CCO)CC(=NN1C(=O)Nc1ccc(F)cc1)c1ccncc1 |c:13| Show InChI InChI=1S/C24H23FN4O2/c1-17-2-4-19(5-3-17)24(12-15-30)16-22(18-10-13-26-14-11-18)28-29(24)23(31)27-21-8-6-20(25)7-9-21/h2-11,13-14,30H,12,15-16H2,1H3,(H,27,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Inhibition of recombinant T-type calcium channel Cav1.2 (unknown origin) expressed in HEK293 cells assessed as inhibition of Kcl-induced calcium infl... |
J Med Chem 59: 8398-411 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00756 BindingDB Entry DOI: 10.7270/Q2J67JWK |
More data for this Ligand-Target Pair | |