Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cathepsin H
(Capra hircus (Goat)) | BDBM150780
(2-(4-Methylphenyl)-2,3-dihydroquinazolin-4(1H)-one...)Show InChI InChI=1S/C15H14N2O/c1-10-6-8-11(9-7-10)14-16-13-5-3-2-4-12(13)15(18)17-14/h2-9,14,16H,1H3,(H,17,18) | PDB MMDB
KEGG
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
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PC cid PC sid UniChem
Similars
| Article PubMed
| 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 6.0 | n/a |
Kurukshetra University
| Assay Description Cathepsin B and H were first activated in the presence of thiol activators at pH 6.0 and pH 7.0, respectively. Then, 15 µL of the enzyme solution was... |
Bioorg Chem 59: 12-22 (2015)
Article DOI: 10.1016/j.bioorg.2015.01.005 BindingDB Entry DOI: 10.7270/Q2DZ071B |
More data for this Ligand-Target Pair | |
Cathepsin B
(Capra hircus (Goat)) | BDBM150780
(2-(4-Methylphenyl)-2,3-dihydroquinazolin-4(1H)-one...)Show InChI InChI=1S/C15H14N2O/c1-10-6-8-11(9-7-10)14-16-13-5-3-2-4-12(13)15(18)17-14/h2-9,14,16H,1H3,(H,17,18) | PDB MMDB
KEGG
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| 5.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 6.0 | n/a |
Kurukshetra University
| Assay Description Cathepsin B and H were first activated in the presence of thiol activators at pH 6.0 and pH 7.0, respectively. Then, 15 µL of the enzyme solution was... |
Bioorg Chem 59: 12-22 (2015)
Article DOI: 10.1016/j.bioorg.2015.01.005 BindingDB Entry DOI: 10.7270/Q2DZ071B |
More data for this Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM150780
(2-(4-Methylphenyl)-2,3-dihydroquinazolin-4(1H)-one...)Show InChI InChI=1S/C15H14N2O/c1-10-6-8-11(9-7-10)14-16-13-5-3-2-4-12(13)15(18)17-14/h2-9,14,16H,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu
Curated by ChEMBL
| Assay Description Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assay |
Bioorg Med Chem 23: 4139-49 (2015)
Article DOI: 10.1016/j.bmc.2015.06.063
BindingDB Entry DOI: 10.7270/Q2W66NJ2 |
More data for this Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM150780
(2-(4-Methylphenyl)-2,3-dihydroquinazolin-4(1H)-one...)Show InChI InChI=1S/C15H14N2O/c1-10-6-8-11(9-7-10)14-16-13-5-3-2-4-12(13)15(18)17-14/h2-9,14,16H,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu
Curated by ChEMBL
| Assay Description Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assay |
Bioorg Med Chem 23: 4139-49 (2015)
Article DOI: 10.1016/j.bmc.2015.06.063
BindingDB Entry DOI: 10.7270/Q2W66NJ2 |
More data for this Ligand-Target Pair | |