Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin E synthase
(Homo sapiens (Human)) | BDBM50397234
(CHEMBL2172767)Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)Cc1cn(nc1-c1ccc(cc1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C30H25N3O3S/c1-22-12-18-28(19-13-22)37(35,36)32-29(34)20-26-21-33(27-10-6-3-7-11-27)31-30(26)25-16-14-24(15-17-25)23-8-4-2-5-9-23/h2-19,21H,20H2,1H3,(H,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard Karls University
Curated by ChEMBL
| Assay Description
Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as inhibition of PGE2 formation from PGH2 after 15 mins by RP-HPLC a... |
J Med Chem 55: 8958-62 (2012)
Article DOI: 10.1021/jm3010543
BindingDB Entry DOI: 10.7270/Q20Z74FD |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50397234
(CHEMBL2172767)Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)Cc1cn(nc1-c1ccc(cc1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C30H25N3O3S/c1-22-12-18-28(19-13-22)37(35,36)32-29(34)20-26-21-33(27-10-6-3-7-11-27)31-30(26)25-16-14-24(15-17-25)23-8-4-2-5-9-23/h2-19,21H,20H2,1H3,(H,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard Karls University
Curated by ChEMBL
| Assay Description
Inhibition of 5-lipoxygenase in A23187-stimulated human neutrophils assessed as inhibition of enzyme product formation by RP-HPLC analysis |
J Med Chem 55: 8958-62 (2012)
Article DOI: 10.1021/jm3010543
BindingDB Entry DOI: 10.7270/Q20Z74FD |
More data for this
Ligand-Target Pair | |