Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Stearoyl-CoA desaturase
(Homo sapiens (Human)) | BDBM50448677
(CHEMBL3127664 | US9102669, 9)Show SMILES Cc1ccc2CCN(C3CCN(CC3)c3ccc(nn3)-c3cnn(C)c3)c2c1 Show InChI InChI=1S/C22H26N6/c1-16-3-4-17-7-12-28(21(17)13-16)19-8-10-27(11-9-19)22-6-5-20(24-25-22)18-14-23-26(2)15-18/h3-6,13-15,19H,7-12H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 241 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of SCD1 in human A431 cells assessed as [13C]-palmitic acid conversion to [13C]-palmitoleic acid after 4 hrs by LC/MS analysis |
Bioorg Med Chem Lett 24: 1437-41 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.075
BindingDB Entry DOI: 10.7270/Q26M38BM |
More data for this
Ligand-Target Pair | |
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50448677
(CHEMBL3127664 | US9102669, 9)Show SMILES Cc1ccc2CCN(C3CCN(CC3)c3ccc(nn3)-c3cnn(C)c3)c2c1 Show InChI InChI=1S/C22H26N6/c1-16-3-4-17-7-12-28(21(17)13-16)19-8-10-27(11-9-19)22-6-5-20(24-25-22)18-14-23-26(2)15-18/h3-6,13-15,19H,7-12H2,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 286 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of SCD1 in Sprague-Dawley rat liver microsomes using stearoyl-[9,10-3H]-CoA as substrate |
Bioorg Med Chem Lett 24: 1437-41 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.075
BindingDB Entry DOI: 10.7270/Q26M38BM |
More data for this
Ligand-Target Pair | |
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50448677
(CHEMBL3127664 | US9102669, 9)Show SMILES Cc1ccc2CCN(C3CCN(CC3)c3ccc(nn3)-c3cnn(C)c3)c2c1 Show InChI InChI=1S/C22H26N6/c1-16-3-4-17-7-12-28(21(17)13-16)19-8-10-27(11-9-19)22-6-5-20(24-25-22)18-14-23-26(2)15-18/h3-6,13-15,19H,7-12H2,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 422 | n/a | n/a | n/a | n/a | n/a | 25 |
Janssen Pharmaceutica NV
US Patent
| Assay Description
The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e... |
US Patent US9102669 (2015)
BindingDB Entry DOI: 10.7270/Q2BC3X9V |
More data for this
Ligand-Target Pair | |