Found 7 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM295029
(3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol...)Show SMILES Cc1cccc(NS(=O)(=O)c2ccc(C)c(c2)-c2cnc(N)c(c2)-c2cnn(CC(F)(F)F)c2)n1 Show InChI InChI=1S/C23H21F3N6O2S/c1-14-6-7-18(35(33,34)31-21-5-3-4-15(2)30-21)9-19(14)16-8-20(22(27)28-10-16)17-11-29-32(12-17)13-23(24,25)26/h3-12H,13H2,1-2H3,(H2,27,28)(H,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG
US Patent
| Assay Description The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t... |
US Patent US10112926 (2018)
BindingDB Entry DOI: 10.7270/Q22R3TQ9 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM295029
(3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol...)Show SMILES Cc1cccc(NS(=O)(=O)c2ccc(C)c(c2)-c2cnc(N)c(c2)-c2cnn(CC(F)(F)F)c2)n1 Show InChI InChI=1S/C23H21F3N6O2S/c1-14-6-7-18(35(33,34)31-21-5-3-4-15(2)30-21)9-19(14)16-8-20(22(27)28-10-16)17-11-29-32(12-17)13-23(24,25)26/h3-12H,13H2,1-2H3,(H2,27,28)(H,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG
US Patent
| Assay Description The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t... |
US Patent US10112926 (2018)
BindingDB Entry DOI: 10.7270/Q22R3TQ9 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha
(Homo sapiens (Human)) | BDBM295029
(3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol...)Show SMILES Cc1cccc(NS(=O)(=O)c2ccc(C)c(c2)-c2cnc(N)c(c2)-c2cnn(CC(F)(F)F)c2)n1 Show InChI InChI=1S/C23H21F3N6O2S/c1-14-6-7-18(35(33,34)31-21-5-3-4-15(2)30-21)9-19(14)16-8-20(22(27)28-10-16)17-11-29-32(12-17)13-23(24,25)26/h3-12H,13H2,1-2H3,(H2,27,28)(H,30,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10112926 (2018)
BindingDB Entry DOI: 10.7270/Q22R3TQ9 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM295029
(3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol...)Show SMILES Cc1cccc(NS(=O)(=O)c2ccc(C)c(c2)-c2cnc(N)c(c2)-c2cnn(CC(F)(F)F)c2)n1 Show InChI InChI=1S/C23H21F3N6O2S/c1-14-6-7-18(35(33,34)31-21-5-3-4-15(2)30-21)9-19(14)16-8-20(22(27)28-10-16)17-11-29-32(12-17)13-23(24,25)26/h3-12H,13H2,1-2H3,(H2,27,28)(H,30,31) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.95E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10112926 (2018)
BindingDB Entry DOI: 10.7270/Q22R3TQ9 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM295029
(3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol...)Show SMILES Cc1cccc(NS(=O)(=O)c2ccc(C)c(c2)-c2cnc(N)c(c2)-c2cnn(CC(F)(F)F)c2)n1 Show InChI InChI=1S/C23H21F3N6O2S/c1-14-6-7-18(35(33,34)31-21-5-3-4-15(2)30-21)9-19(14)16-8-20(22(27)28-10-16)17-11-29-32(12-17)13-23(24,25)26/h3-12H,13H2,1-2H3,(H2,27,28)(H,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.37E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG
US Patent
| Assay Description Binding Assays are based on the binding and displacement of an Alexa Fluor 647-labeled, ATP-competitive kinase inhibitors to the kinase of interest. ... |
US Patent US10112926 (2018)
BindingDB Entry DOI: 10.7270/Q22R3TQ9 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM295029
(3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol...)Show SMILES Cc1cccc(NS(=O)(=O)c2ccc(C)c(c2)-c2cnc(N)c(c2)-c2cnn(CC(F)(F)F)c2)n1 Show InChI InChI=1S/C23H21F3N6O2S/c1-14-6-7-18(35(33,34)31-21-5-3-4-15(2)30-21)9-19(14)16-8-20(22(27)28-10-16)17-11-29-32(12-17)13-23(24,25)26/h3-12H,13H2,1-2H3,(H2,27,28)(H,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4.05E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10112926 (2018)
BindingDB Entry DOI: 10.7270/Q22R3TQ9 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase catalytic subunit type 3
(Homo sapiens (Human)) | BDBM295029
(3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol...)Show SMILES Cc1cccc(NS(=O)(=O)c2ccc(C)c(c2)-c2cnc(N)c(c2)-c2cnn(CC(F)(F)F)c2)n1 Show InChI InChI=1S/C23H21F3N6O2S/c1-14-6-7-18(35(33,34)31-21-5-3-4-15(2)30-21)9-19(14)16-8-20(22(27)28-10-16)17-11-29-32(12-17)13-23(24,25)26/h3-12H,13H2,1-2H3,(H2,27,28)(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >9.10E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10112926 (2018)
BindingDB Entry DOI: 10.7270/Q22R3TQ9 |
More data for this Ligand-Target Pair | |