Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Stearoyl-CoA desaturase
(Homo sapiens (Human)) | BDBM50304951
(CHEMBL591781 | N-(2-(4-fluorophenyl)-2-hydroxyethy...)Show SMILES Cc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1ccc(F)cc1 Show InChI InChI=1S/C26H27FN4O3/c1-17-4-2-3-5-21(17)25(33)19-12-14-31(15-13-19)24-11-10-22(29-30-24)26(34)28-16-23(32)18-6-8-20(27)9-7-18/h2-11,19,23,32H,12-16H2,1H3,(H,28,34) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of Scd1 in human HEK-293A cell microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 ... |
Bioorg Med Chem Lett 20: 341-5 (2010)
Article DOI: 10.1016/j.bmcl.2009.10.101 BindingDB Entry DOI: 10.7270/Q23X86R7 |
More data for this Ligand-Target Pair | |
Acyl-CoA desaturase 1
(Mus musculus) | BDBM50304951
(CHEMBL591781 | N-(2-(4-fluorophenyl)-2-hydroxyethy...)Show SMILES Cc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1ccc(F)cc1 Show InChI InChI=1S/C26H27FN4O3/c1-17-4-2-3-5-21(17)25(33)19-12-14-31(15-13-19)24-11-10-22(29-30-24)26(34)28-16-23(32)18-6-8-20(27)9-7-18/h2-11,19,23,32H,12-16H2,1H3,(H,28,34) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of Scd1 in mouse liver microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 mins |
Bioorg Med Chem Lett 20: 341-5 (2010)
Article DOI: 10.1016/j.bmcl.2009.10.101 BindingDB Entry DOI: 10.7270/Q23X86R7 |
More data for this Ligand-Target Pair | |
Stearoyl-CoA desaturase
(Homo sapiens (Human)) | BDBM50304951
(CHEMBL591781 | N-(2-(4-fluorophenyl)-2-hydroxyethy...)Show SMILES Cc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1ccc(F)cc1 Show InChI InChI=1S/C26H27FN4O3/c1-17-4-2-3-5-21(17)25(33)19-12-14-31(15-13-19)24-11-10-22(29-30-24)26(34)28-16-23(32)18-6-8-20(27)9-7-18/h2-11,19,23,32H,12-16H2,1H3,(H,28,34) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of human Scd1 expressed in HEK-293A cells assessed as conversion of [14C]stearate to [14C]oleate pretreated for 30 mins measured after 4 h... |
Bioorg Med Chem Lett 20: 341-5 (2010)
Article DOI: 10.1016/j.bmcl.2009.10.101 BindingDB Entry DOI: 10.7270/Q23X86R7 |
More data for this Ligand-Target Pair | |