Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Proline-rich AKT1 substrate 1
(Homo sapiens (Human)) | BDBM386043
(4-(4-(2-(piperidin-1-yl)-1-(o-tolyl)ethyl)piperazi...)Show SMILES Cc1ccccc1C(CN1CCCCC1)N1CCN(CC1)c1ncnc2NCC(=O)Nc12 Show InChI InChI=1S/C24H33N7O/c1-18-7-3-4-8-19(18)20(16-29-9-5-2-6-10-29)30-11-13-31(14-12-30)24-22-23(26-17-27-24)25-15-21(32)28-22/h3-4,7-8,17,20H,2,5-6,9-16H2,1H3,(H,28,32)(H,25,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description
A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1 [T412E]
(Homo sapiens (Human)) | BDBM386043
(4-(4-(2-(piperidin-1-yl)-1-(o-tolyl)ethyl)piperazi...)Show SMILES Cc1ccccc1C(CN1CCCCC1)N1CCN(CC1)c1ncnc2NCC(=O)Nc12 Show InChI InChI=1S/C24H33N7O/c1-18-7-3-4-8-19(18)20(16-29-9-5-2-6-10-29)30-11-13-31(14-12-30)24-22-23(26-17-27-24)25-15-21(32)28-22/h3-4,7-8,17,20H,2,5-6,9-16H2,1H3,(H,28,32)(H,25,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this
Ligand-Target Pair | |