Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 394.8 BDBM50159560

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 2 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50159560 (CHEMBL3785245) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)Cc3ccccc3C2=O)c(Cl)c1 Show InChI InChI=1S/C21H15ClN2O4/c1-12-8-9-28-19(12)20(26)23-14-6-7-17(16(22)11-14)24-18(25)10-13-4-2-3-5-15(13)21(24)27/h2-9,11H,10H2,1H3,(H,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	242	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...				Bioorg Med Chem Lett 26: 1869-72 (2016) Article DOI: 10.1016/j.bmcl.2016.03.031 BindingDB Entry DOI: 10.7270/Q2Z03B11
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50159560 (CHEMBL3785245) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)Cc3ccccc3C2=O)c(Cl)c1 Show InChI InChI=1S/C21H15ClN2O4/c1-12-8-9-28-19(12)20(26)23-14-6-7-17(16(22)11-14)24-18(25)10-13-4-2-3-5-15(13)21(24)27/h2-9,11H,10H2,1H3,(H,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	224	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...				Bioorg Med Chem Lett 26: 1869-72 (2016) Article DOI: 10.1016/j.bmcl.2016.03.031 BindingDB Entry DOI: 10.7270/Q2Z03B11
					More data for this Ligand-Target Pair