Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM145828
(US8952177, 184 | US9089569, 184 | US9695149, 184)Show SMILES Cc1cnc(COc2ccc3nc(CC(C)(C)C(O)=O)n(Cc4ccc(cc4)N4CCC(CC4)C(C)(C)C)c3c2)c(F)c1 Show InChI InChI=1S/C35H43FN4O3/c1-23-17-28(36)30(37-20-23)22-43-27-11-12-29-31(18-27)40(32(38-29)19-35(5,6)33(41)42)21-24-7-9-26(10-8-24)39-15-13-25(14-16-39)34(2,3)4/h7-12,17-18,20,25H,13-16,19,21-22H2,1-6H3,(H,41,42) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in... |
US Patent US8952177 (2015)
BindingDB Entry DOI: 10.7270/Q2G73CFW |
More data for this
Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM145828
(US8952177, 184 | US9089569, 184 | US9695149, 184)Show SMILES Cc1cnc(COc2ccc3nc(CC(C)(C)C(O)=O)n(Cc4ccc(cc4)N4CCC(CC4)C(C)(C)C)c3c2)c(F)c1 Show InChI InChI=1S/C35H43FN4O3/c1-23-17-28(36)30(37-20-23)22-43-27-11-12-29-31(18-27)40(32(38-29)19-35(5,6)33(41)42)21-24-7-9-26(10-8-24)39-15-13-25(14-16-39)34(2,3)4/h7-12,17-18,20,25H,13-16,19,21-22H2,1-6H3,(H,41,42) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9695149 (2017)
BindingDB Entry DOI: 10.7270/Q2Q52MSC |
More data for this
Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM145828
(US8952177, 184 | US9089569, 184 | US9695149, 184)Show SMILES Cc1cnc(COc2ccc3nc(CC(C)(C)C(O)=O)n(Cc4ccc(cc4)N4CCC(CC4)C(C)(C)C)c3c2)c(F)c1 Show InChI InChI=1S/C35H43FN4O3/c1-23-17-28(36)30(37-20-23)22-43-27-11-12-29-31(18-27)40(32(38-29)19-35(5,6)33(41)42)21-24-7-9-26(10-8-24)39-15-13-25(14-16-39)34(2,3)4/h7-12,17-18,20,25H,13-16,19,21-22H2,1-6H3,(H,41,42) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9089569 (2015)
BindingDB Entry DOI: 10.7270/Q23X85DB |
More data for this
Ligand-Target Pair | |