Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 338.3 BDBM50330706

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NADPH oxidase 4 (Homo sapiens (Human))	BDBM50330706 (4,5-dimethyl-2-(4-phenylthiazol-2-yl)-1H-pyrazolo[...) Show SMILES Cc1n(C)c(=O)cc2[nH]n(-c3nc(cs3)-c3ccccc3)c(=O)c12 Show InChI InChI=1S/C17H14N4O2S/c1-10-15-12(8-14(22)20(10)2)19-21(16(15)23)17-18-13(9-24-17)11-6-4-3-5-7-11/h3-9,19H,1-2H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	1.95E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genkyotex, S.A. Curated by ChEMBL					Assay Description Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH				J Med Chem 53: 7715-30 (2010) Article DOI: 10.1021/jm100773e BindingDB Entry DOI: 10.7270/Q2KH0NKJ
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