Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human)) | BDBM50538995
(CHEMBL4642156)Show SMILES Cc1n(C)nc2ccc3c(NCc4ccc(cc4)C(=O)NC4CCCC4)ncnc3c12 Show InChI InChI=1S/C24H26N6O/c1-15-21-20(29-30(15)2)12-11-19-22(21)26-14-27-23(19)25-13-16-7-9-17(10-8-16)24(31)28-18-5-3-4-6-18/h7-12,14,18H,3-6,13H2,1-2H3,(H,28,31)(H,25,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 239 | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce... |
Bioorg Med Chem Lett 30: (2020)
Article DOI: 10.1016/j.bmcl.2019.126811
BindingDB Entry DOI: 10.7270/Q2J67MG1 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M4
(RAT) | BDBM50538995
(CHEMBL4642156)Show SMILES Cc1n(C)nc2ccc3c(NCc4ccc(cc4)C(=O)NC4CCCC4)ncnc3c12 Show InChI InChI=1S/C24H26N6O/c1-15-21-20(29-30(15)2)12-11-19-22(21)26-14-27-23(19)25-13-16-7-9-17(10-8-16)24(31)28-18-5-3-4-6-18/h7-12,14,18H,3-6,13H2,1-2H3,(H,28,31)(H,25,26,27) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 168 | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of rat muscarinic M4 receptor |
Bioorg Med Chem Lett 30: (2020)
Article DOI: 10.1016/j.bmcl.2019.126811
BindingDB Entry DOI: 10.7270/Q2J67MG1 |
More data for this
Ligand-Target Pair | |