Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 604.0 BDBM104817

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysosomal Pro-X carboxypeptidase (Homo sapiens (Human))	BDBM104817 (US8569299, 3) Show SMILES Cc1nc(C2CCN(CC2)C(=O)[C@@H]2CC(C[C@H]2c2ccc(F)cc2F)N2CCC(F)(F)C2)n(n1)-c1ccc(Cl)c(C)c1 |r| Show InChI InChI=1S/C31H34ClF4N5O/c1-18-13-22(4-6-27(18)32)41-29(37-19(2)38-41)20-7-10-39(11-8-20)30(42)26-16-23(40-12-9-31(35,36)17-40)15-25(26)24-5-3-21(33)14-28(24)34/h3-6,13-14,20,23,25-26H,7-12,15-17H2,1-2H3/t23?,25-,26+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.80	n/a	n/a	n/a	n/a	5.5	37
Merck Sharp & Dohme Corp US Patent					Assay Description The potency of compounds against PRCP was determined by a fluorescence intensity kinetic assay measuring the IC50 values of PRCP inhibitor test compo...				US Patent US8569299 (2013) BindingDB Entry DOI: 10.7270/Q2K9365V
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