Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359190
(US10220048, Compound AA100 | US10952992, No. AA100...)Show SMILES Cc1nc(Cc2nnc(N[C@@H](Cc3ccc(NS(O)(=O)=O)cc3)c3csc(n3)-c3cccs3)s2)cs1 |r| Show InChI InChI=1S/C22H20N6O3S5/c1-13-23-16(11-33-13)10-20-26-27-22(35-20)25-17(18-12-34-21(24-18)19-3-2-8-32-19)9-14-4-6-15(7-5-14)28-36(29,30)31/h2-8,11-12,17,28H,9-10H2,1H3,(H,25,27)(H,29,30,31)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Non-limiting examples of the HPTPβ IC50 (μM) activity. |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2668HD5 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359190
(US10220048, Compound AA100 | US10952992, No. AA100...)Show SMILES Cc1nc(Cc2nnc(N[C@@H](Cc3ccc(NS(O)(=O)=O)cc3)c3csc(n3)-c3cccs3)s2)cs1 |r| Show InChI InChI=1S/C22H20N6O3S5/c1-13-23-16(11-33-13)10-20-26-27-22(35-20)25-17(18-12-34-21(24-18)19-3-2-8-32-19)9-14-4-6-15(7-5-14)28-36(29,30)31/h2-8,11-12,17,28H,9-10H2,1H3,(H,25,27)(H,29,30,31)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RV0SPJ |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359190
(US10220048, Compound AA100 | US10952992, No. AA100...)Show SMILES Cc1nc(Cc2nnc(N[C@@H](Cc3ccc(NS(O)(=O)=O)cc3)c3csc(n3)-c3cccs3)s2)cs1 |r| Show InChI InChI=1S/C22H20N6O3S5/c1-13-23-16(11-33-13)10-20-26-27-22(35-20)25-17(18-12-34-21(24-18)19-3-2-8-32-19)9-14-4-6-15(7-5-14)28-36(29,30)31/h2-8,11-12,17,28H,9-10H2,1H3,(H,25,27)(H,29,30,31)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO THERAPEUTICS, INC.
US Patent
| Assay Description HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N... |
US Patent US10220048 (2019)
BindingDB Entry DOI: 10.7270/Q2VT1VC9 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359190
(US10220048, Compound AA100 | US10952992, No. AA100...)Show SMILES Cc1nc(Cc2nnc(N[C@@H](Cc3ccc(NS(O)(=O)=O)cc3)c3csc(n3)-c3cccs3)s2)cs1 |r| Show InChI InChI=1S/C22H20N6O3S5/c1-13-23-16(11-33-13)10-20-26-27-22(35-20)25-17(18-12-34-21(24-18)19-3-2-8-32-19)9-14-4-6-15(7-5-14)28-36(29,30)31/h2-8,11-12,17,28H,9-10H2,1H3,(H,25,27)(H,29,30,31)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO PHARMACEUTICALS, INC.
US Patent
| Assay Description Non-limiting examples of the HPTP-β IC50 (μM) activity. |
US Patent US10952992 (2021)
BindingDB Entry DOI: 10.7270/Q2FR00R3 |
More data for this Ligand-Target Pair | |