Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cGMP-dependent protein kinase
(Plasmodium falciparum) | BDBM50530664
(CHEMBL4548154)Show SMILES Cc1nc(Nc2nccc(n2)-c2sc(nc2-c2ccc(F)cc2)C2CCNCC2)cc(C2CCC2)c1F Show InChI InChI=1S/C28H28F2N6S/c1-16-24(30)21(17-3-2-4-17)15-23(33-16)35-28-32-14-11-22(34-28)26-25(18-5-7-20(29)8-6-18)36-27(37-26)19-9-12-31-13-10-19/h5-8,11,14-15,17,19,31H,2-4,9-10,12-13H2,1H3,(H,32,33,34,35) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of Plasmodium falciparum full length N-terminal His-tagged PKG expressed in Escherichia coli RosettaTM 2(DE3) pLysS cells using FAM-GRTGRR... |
J Med Chem 62: 9217-9235 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01099
BindingDB Entry DOI: 10.7270/Q2X63RDP |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Plasmodium falciparum) | BDBM50530664
(CHEMBL4548154)Show SMILES Cc1nc(Nc2nccc(n2)-c2sc(nc2-c2ccc(F)cc2)C2CCNCC2)cc(C2CCC2)c1F Show InChI InChI=1S/C28H28F2N6S/c1-16-24(30)21(17-3-2-4-17)15-23(33-16)35-28-32-14-11-22(34-28)26-25(18-5-7-20(29)8-6-18)36-27(37-26)19-9-12-31-13-10-19/h5-8,11,14-15,17,19,31H,2-4,9-10,12-13H2,1H3,(H,32,33,34,35) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of Plasmodium falciparum full length N-terminal His-tagged PKG expressed in Escherichia coli RosettaTM 2(DE3) pLysS cells using FAM-GRTGRR... |
J Med Chem 62: 9217-9235 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01099
BindingDB Entry DOI: 10.7270/Q2X63RDP |
More data for this
Ligand-Target Pair | |