Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50446147
(CHEMBL3108783 | US9518026, Example 32 | US9956214,...)Show SMILES Cc1nc2cc(ccc2n1C)-c1nn(c(N)c1C(N)=O)C(C)(C)C Show InChI InChI=1S/C17H22N6O/c1-9-20-11-8-10(6-7-12(11)22(9)5)14-13(16(19)24)15(18)23(21-14)17(2,3)4/h6-8H,18H2,1-5H3,(H2,19,24) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrate |
ACS Med Chem Lett 5: 40-44 (2014)
Article DOI: 10.1021/ml400315s BindingDB Entry DOI: 10.7270/Q28917BZ |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50446147
(CHEMBL3108783 | US9518026, Example 32 | US9956214,...)Show SMILES Cc1nc2cc(ccc2n1C)-c1nn(c(N)c1C(N)=O)C(C)(C)C Show InChI InChI=1S/C17H22N6O/c1-9-20-11-8-10(6-7-12(11)22(9)5)14-13(16(19)24)15(18)23(21-14)17(2,3)4/h6-8H,18H2,1-5H3,(H2,19,24) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM50446147
(CHEMBL3108783 | US9518026, Example 32 | US9956214,...)Show SMILES Cc1nc2cc(ccc2n1C)-c1nn(c(N)c1C(N)=O)C(C)(C)C Show InChI InChI=1S/C17H22N6O/c1-9-20-11-8-10(6-7-12(11)22(9)5)14-13(16(19)24)15(18)23(21-14)17(2,3)4/h6-8H,18H2,1-5H3,(H2,19,24) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50446147
(CHEMBL3108783 | US9518026, Example 32 | US9956214,...)Show SMILES Cc1nc2cc(ccc2n1C)-c1nn(c(N)c1C(N)=O)C(C)(C)C Show InChI InChI=1S/C17H22N6O/c1-9-20-11-8-10(6-7-12(11)22(9)5)14-13(16(19)24)15(18)23(21-14)17(2,3)4/h6-8H,18H2,1-5H3,(H2,19,24) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Uncharacterized protein
(Cryptosporidium parvum) | BDBM50446147
(CHEMBL3108783 | US9518026, Example 32 | US9956214,...)Show SMILES Cc1nc2cc(ccc2n1C)-c1nn(c(N)c1C(N)=O)C(C)(C)C Show InChI InChI=1S/C17H22N6O/c1-9-20-11-8-10(6-7-12(11)22(9)5)14-13(16(19)24)15(18)23(21-14)17(2,3)4/h6-8H,18H2,1-5H3,(H2,19,24) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |