Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 316.7 BDBM372315

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM372315 (8-chloro-N-(cyclobutyl- methyl)-7,9-dimethyl- pyri...) Show SMILES Cc1nc2oc3c(NCC4CCC4)ncnc3c2c(C)c1Cl Show InChI InChI=1S/C16H17ClN4O/c1-8-11-13-14(22-16(11)21-9(2)12(8)17)15(20-7-19-13)18-6-10-4-3-5-10/h7,10H,3-6H2,1-2H3,(H,18,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.53E+3	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q2W09880
					More data for this Ligand-Target Pair