Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 3-kinase catalytic subunit type 3
(Homo sapiens (Human)) | BDBM338074
(US9751854, Compound I-249 | US9802960, Compound I-...)Show SMILES Cc1nccc(Nc2cc(ccn2)-c2cnc(C)c(NC(=O)c3ccc(F)cc3F)c2)n1 Show InChI InChI=1S/C23H18F2N6O/c1-13-20(30-23(32)18-4-3-17(24)11-19(18)25)9-16(12-28-13)15-5-7-27-22(10-15)31-21-6-8-26-14(2)29-21/h3-12H,1-2H3,(H,30,32)(H,26,27,29,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
US Patent
| Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro... |
US Patent US9802960 (2017)
BindingDB Entry DOI: 10.7270/Q2D79DJ9 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase catalytic subunit type 3
(Homo sapiens (Human)) | BDBM338074
(US9751854, Compound I-249 | US9802960, Compound I-...)Show SMILES Cc1nccc(Nc2cc(ccn2)-c2cnc(C)c(NC(=O)c3ccc(F)cc3F)c2)n1 Show InChI InChI=1S/C23H18F2N6O/c1-13-20(30-23(32)18-4-3-17(24)11-19(18)25)9-16(12-28-13)15-5-7-27-22(10-15)31-21-6-8-26-14(2)29-21/h3-12H,1-2H3,(H,30,32)(H,26,27,29,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
US Patent
| Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro... |
US Patent US9751854 (2017)
BindingDB Entry DOI: 10.7270/Q2KS6TNJ |
More data for this
Ligand-Target Pair | |