Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 3-kinase catalytic subunit type 3
(Homo sapiens (Human)) | BDBM338256
(US9751854, Compound I-440 | US9802960, Compound I-...)Show SMILES Cc1nccc(Nc2cc(ccn2)-c2cncc(OC3CCc4c3cccc4F)c2)n1 Show InChI InChI=1S/C24H20FN5O/c1-15-27-10-8-23(29-15)30-24-12-16(7-9-28-24)17-11-18(14-26-13-17)31-22-6-5-19-20(22)3-2-4-21(19)25/h2-4,7-14,22H,5-6H2,1H3,(H,27,28,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
US Patent
| Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro... |
US Patent US9802960 (2017)
BindingDB Entry DOI: 10.7270/Q2D79DJ9 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase catalytic subunit type 3
(Homo sapiens (Human)) | BDBM338256
(US9751854, Compound I-440 | US9802960, Compound I-...)Show SMILES Cc1nccc(Nc2cc(ccn2)-c2cncc(OC3CCc4c3cccc4F)c2)n1 Show InChI InChI=1S/C24H20FN5O/c1-15-27-10-8-23(29-15)30-24-12-16(7-9-28-24)17-11-18(14-26-13-17)31-22-6-5-19-20(22)3-2-4-21(19)25/h2-4,7-14,22H,5-6H2,1H3,(H,27,28,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
US Patent
| Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro... |
US Patent US9751854 (2017)
BindingDB Entry DOI: 10.7270/Q2KS6TNJ |
More data for this
Ligand-Target Pair | |