Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 295.2 BDBM15877

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM15877 (9-hydroxy pyrazoloquinolinone 12c | 9-hydroxy-1,3-...) Show SMILES Cc1nn(C)c2n(O)c3ccc(cc3c(=O)c12)-c1cc[nH]n1 Show InChI InChI=1S/C15H13N5O2/c1-8-13-14(21)10-7-9(11-5-6-16-17-11)3-4-12(10)20(22)15(13)19(2)18-8/h3-7,22H,1-2H3,(H,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.2	20
Abbott Laboratories					Assay Description In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...				Bioorg Med Chem Lett 16: 2590-4 (2006) Article DOI: 10.1016/j.bmcl.2006.02.046 BindingDB Entry DOI: 10.7270/Q2XK8CSR
					More data for this Ligand-Target Pair