Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-secretase 2
(Homo sapiens (Human)) | BDBM259156
(US9499502, 27ay)Show SMILES Cc1nnc(o1)-c1cccc(c1)-c1cc(F)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1 |r| Show InChI InChI=1S/C20H21FN4O3S2/c1-11-24-25-17(28-11)13-7-5-6-12(8-13)15-9-14(21)16(29-15)20(4)10-30(26,27)19(2,3)18(22)23-20/h5-9H,10H2,1-4H3,(H2,22,23)/t20-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| <100 | <-40.6 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEVN... |
US Patent US9499502 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7FJJ |
More data for this
Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM259156
(US9499502, 27ay)Show SMILES Cc1nnc(o1)-c1cccc(c1)-c1cc(F)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1 |r| Show InChI InChI=1S/C20H21FN4O3S2/c1-11-24-25-17(28-11)13-7-5-6-12(8-13)15-9-14(21)16(29-15)20(4)10-30(26,27)19(2,3)18(22)23-20/h5-9H,10H2,1-4H3,(H2,22,23)/t20-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 480 | -36.7 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo... |
US Patent US9499502 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7FJJ |
More data for this
Ligand-Target Pair | |