Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM150076
(US8975417, 136)Show SMILES Cc1nnc2c(C)cc(cn12)N1C(c2c(C)n(nc2C1=O)C1COC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C23H21ClN6O2/c1-12-8-17(9-28-14(3)25-26-22(12)28)29-21(15-4-6-16(24)7-5-15)19-13(2)30(18-10-32-11-18)27-20(19)23(29)31/h4-9,18,21H,10-11H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Novartis AG
US Patent
| Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... |
US Patent US8975417 (2015)
BindingDB Entry DOI: 10.7270/Q2NK3CRX |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM150076
(US8975417, 136)Show SMILES Cc1nnc2c(C)cc(cn12)N1C(c2c(C)n(nc2C1=O)C1COC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C23H21ClN6O2/c1-12-8-17(9-28-14(3)25-26-22(12)28)29-21(15-4-6-16(24)7-5-15)19-13(2)30(18-10-32-11-18)27-20(19)23(29)31/h4-9,18,21H,10-11H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Novartis AG
US Patent
| Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... |
US Patent US8975417 (2015)
BindingDB Entry DOI: 10.7270/Q2NK3CRX |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 2
(Homo sapiens (Human)) | BDBM150076
(US8975417, 136)Show SMILES Cc1nnc2c(C)cc(cn12)N1C(c2c(C)n(nc2C1=O)C1COC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C23H21ClN6O2/c1-12-8-17(9-28-14(3)25-26-22(12)28)29-21(15-4-6-16(24)7-5-15)19-13(2)30(18-10-32-11-18)27-20(19)23(29)31/h4-9,18,21H,10-11H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Novartis AG
US Patent
| Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... |
US Patent US8975417 (2015)
BindingDB Entry DOI: 10.7270/Q2NK3CRX |
More data for this
Ligand-Target Pair | |
CREB-binding protein
(Homo sapiens (Human)) | BDBM150076
(US8975417, 136)Show SMILES Cc1nnc2c(C)cc(cn12)N1C(c2c(C)n(nc2C1=O)C1COC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C23H21ClN6O2/c1-12-8-17(9-28-14(3)25-26-22(12)28)29-21(15-4-6-16(24)7-5-15)19-13(2)30(18-10-32-11-18)27-20(19)23(29)31/h4-9,18,21H,10-11H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Novartis AG
US Patent
| Assay Description
In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ... |
US Patent US8975417 (2015)
BindingDB Entry DOI: 10.7270/Q2NK3CRX |
More data for this
Ligand-Target Pair | |