Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Myc proto-oncogene protein
(Homo sapiens (Human)) | BDBM331520
(2-{11-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-y...)Show SMILES Cc1nnn(C)c1-c1cc2n([C@@H](C3CCOCC3)c3ccccc3)c3cc(cnc3c2cn1)C(C)(C)O |r| Show InChI InChI=1S/C29H32N6O2/c1-18-27(34(4)33-32-18)23-15-24-22(17-30-23)26-25(14-21(16-31-26)29(2,3)36)35(24)28(19-8-6-5-7-9-19)20-10-12-37-13-11-20/h5-9,14-17,20,28,36H,10-13H2,1-4H3/t28-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of c-MYC (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128376 BindingDB Entry DOI: 10.7270/Q2KS6WD7 |
More data for this Ligand-Target Pair | |
Bromodomain-containing protein 4 [1-477]/[333-460]/[44-168]/[44-460]
(Homo sapiens (Human)) | BDBM331520
(2-{11-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-y...)Show SMILES Cc1nnn(C)c1-c1cc2n([C@@H](C3CCOCC3)c3ccccc3)c3cc(cnc3c2cn1)C(C)(C)O |r| Show InChI InChI=1S/C29H32N6O2/c1-18-27(34(4)33-32-18)23-15-24-22(17-30-23)26-25(14-21(16-31-26)29(2,3)36)35(24)28(19-8-6-5-7-9-19)20-10-12-37-13-11-20/h5-9,14-17,20,28,36H,10-13H2,1-4H3/t28-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso... |
US Patent US9725449 (2017)
BindingDB Entry DOI: 10.7270/Q2P55QM6 |
More data for this Ligand-Target Pair | |
Bromodomain-containing protein 4 [1-477]/[333-460]/[44-168]/[44-460]
(Homo sapiens (Human)) | BDBM331520
(2-{11-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-y...)Show SMILES Cc1nnn(C)c1-c1cc2n([C@@H](C3CCOCC3)c3ccccc3)c3cc(cnc3c2cn1)C(C)(C)O |r| Show InChI InChI=1S/C29H32N6O2/c1-18-27(34(4)33-32-18)23-15-24-22(17-30-23)26-25(14-21(16-31-26)29(2,3)36)35(24)28(19-8-6-5-7-9-19)20-10-12-37-13-11-20/h5-9,14-17,20,28,36H,10-13H2,1-4H3/t28-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso... |
US Patent US9725449 (2017)
BindingDB Entry DOI: 10.7270/Q2P55QM6 |
More data for this Ligand-Target Pair | |