Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phenylethanolamine N-methyltransferase
(Bos taurus (bovine)) | BDBM13021
(7-(trichloromethane)sulfonyl-1,2,3,4-tetrahydroiso...)Show InChI InChI=1S/C10H10Cl3NO2S/c11-10(12,13)17(15,16)9-2-1-7-3-4-14-6-8(7)5-9/h1-2,5,14H,3-4,6H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against bovine adrenal phenylethanolamine N-methyltransferase(PNMT) |
J Med Chem 42: 118-34 (1999)
Article DOI: 10.1021/jm980429p BindingDB Entry DOI: 10.7270/Q2K35VBN |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Bos taurus (bovine)) | BDBM13021
(7-(trichloromethane)sulfonyl-1,2,3,4-tetrahydroiso...)Show InChI InChI=1S/C10H10Cl3NO2S/c11-10(12,13)17(15,16)9-2-1-7-3-4-14-6-8(7)5-9/h1-2,5,14H,3-4,6H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 2.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Inhibitory activity against bovine adrenal phenylethanolamine N-methyl-transferase (PNMT) |
Bioorg Med Chem Lett 9: 481-6 (1999)
BindingDB Entry DOI: 10.7270/Q26Q20F9 |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM13021
(7-(trichloromethane)sulfonyl-1,2,3,4-tetrahydroiso...)Show InChI InChI=1S/C10H10Cl3NO2S/c11-10(12,13)17(15,16)9-2-1-7-3-4-14-6-8(7)5-9/h1-2,5,14H,3-4,6H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 6.30E+3 | -30.9 | n/a | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Kansas
| Assay Description Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a... |
J Med Chem 49: 5424-33 (2006)
Article DOI: 10.1021/jm060466d BindingDB Entry DOI: 10.7270/Q2DB802Q |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM13021
(7-(trichloromethane)sulfonyl-1,2,3,4-tetrahydroiso...)Show InChI InChI=1S/C10H10Cl3NO2S/c11-10(12,13)17(15,16)9-2-1-7-3-4-14-6-8(7)5-9/h1-2,5,14H,3-4,6H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 1.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Inhibition of [3H]clonidine binding to the rat alpha-2-adrenoceptor |
Bioorg Med Chem Lett 9: 481-6 (1999)
BindingDB Entry DOI: 10.7270/Q26Q20F9 |
More data for this Ligand-Target Pair | |