Found 8 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393902
(US10597367, Example 199 | US9969726, Example 199)Show SMILES Clc1cc(ccn1)C1=Nc2ccc(cc2NC(=O)C1)-c1ccc(Br)nc1 |t:8| Show InChI InChI=1S/C19H12BrClN4O/c20-17-4-2-13(10-23-17)11-1-3-14-16(7-11)25-19(26)9-15(24-14)12-5-6-22-18(21)8-12/h1-8,10H,9H2,(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393902
(US10597367, Example 199 | US9969726, Example 199)Show SMILES Clc1cc(ccn1)C1=Nc2ccc(cc2NC(=O)C1)-c1ccc(Br)nc1 |t:8| Show InChI InChI=1S/C19H12BrClN4O/c20-17-4-2-13(10-23-17)11-1-3-14-16(7-11)25-19(26)9-15(24-14)12-5-6-22-18(21)8-12/h1-8,10H,9H2,(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.27E+3 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM393902
(US10597367, Example 199 | US9969726, Example 199)Show SMILES Clc1cc(ccn1)C1=Nc2ccc(cc2NC(=O)C1)-c1ccc(Br)nc1 |t:8| Show InChI InChI=1S/C19H12BrClN4O/c20-17-4-2-13(10-23-17)11-1-3-14-16(7-11)25-19(26)9-15(24-14)12-5-6-22-18(21)8-12/h1-8,10H,9H2,(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.82E+3 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM393902
(US10597367, Example 199 | US9969726, Example 199)Show SMILES Clc1cc(ccn1)C1=Nc2ccc(cc2NC(=O)C1)-c1ccc(Br)nc1 |t:8| Show InChI InChI=1S/C19H12BrClN4O/c20-17-4-2-13(10-23-17)11-1-3-14-16(7-11)25-19(26)9-15(24-14)12-5-6-22-18(21)8-12/h1-8,10H,9H2,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393902
(US10597367, Example 199 | US9969726, Example 199)Show SMILES Clc1cc(ccn1)C1=Nc2ccc(cc2NC(=O)C1)-c1ccc(Br)nc1 |t:8| Show InChI InChI=1S/C19H12BrClN4O/c20-17-4-2-13(10-23-17)11-1-3-14-16(7-11)25-19(26)9-15(24-14)12-5-6-22-18(21)8-12/h1-8,10H,9H2,(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393902
(US10597367, Example 199 | US9969726, Example 199)Show SMILES Clc1cc(ccn1)C1=Nc2ccc(cc2NC(=O)C1)-c1ccc(Br)nc1 |t:8| Show InChI InChI=1S/C19H12BrClN4O/c20-17-4-2-13(10-23-17)11-1-3-14-16(7-11)25-19(26)9-15(24-14)12-5-6-22-18(21)8-12/h1-8,10H,9H2,(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.27E+3 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM393902
(US10597367, Example 199 | US9969726, Example 199)Show SMILES Clc1cc(ccn1)C1=Nc2ccc(cc2NC(=O)C1)-c1ccc(Br)nc1 |t:8| Show InChI InChI=1S/C19H12BrClN4O/c20-17-4-2-13(10-23-17)11-1-3-14-16(7-11)25-19(26)9-15(24-14)12-5-6-22-18(21)8-12/h1-8,10H,9H2,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.82E+3 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM393902
(US10597367, Example 199 | US9969726, Example 199)Show SMILES Clc1cc(ccn1)C1=Nc2ccc(cc2NC(=O)C1)-c1ccc(Br)nc1 |t:8| Show InChI InChI=1S/C19H12BrClN4O/c20-17-4-2-13(10-23-17)11-1-3-14-16(7-11)25-19(26)9-15(24-14)12-5-6-22-18(21)8-12/h1-8,10H,9H2,(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |