Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 549.0 BDBM50318172

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50318172 (CHEMBL1095087 | N-(4-chlorobenzyl)-2-(2-morpholin-...) Show SMILES Clc1ccc(CNC(=O)c2cn3c(CCN4CCOCC4)cc4cc(CN5CCOCC5)cc(c34)c2=O)cc1 Show InChI InChI=1S/C30H33ClN4O4/c31-24-3-1-21(2-4-24)18-32-30(37)27-20-35-25(5-6-33-7-11-38-12-8-33)17-23-15-22(16-26(28(23)35)29(27)36)19-34-9-13-39-14-10-34/h1-4,15-17,20H,5-14,18-19H2,(H,32,37)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase alpha				Bioorg Med Chem Lett 20: 3039-42 (2010) Article DOI: 10.1016/j.bmcl.2010.03.115 BindingDB Entry DOI: 10.7270/Q2000281
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