Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 284.7 BDBM50550063

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 2 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50550063 (CHEMBL1375223) Show SMILES Clc1ccc(NC(=O)CC2SCCNC2=O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to full length biotinylated 6His/Avi-tagged/Tev-fused human MEK1 expressed in Escherichia coli in presence of AMP-PNP by SPR assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00563 BindingDB Entry DOI: 10.7270/Q2PZ5DF5
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50550063 (CHEMBL1375223) Show SMILES Clc1ccc(NC(=O)CC2SCCNC2=O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to full length biotinylated 6His/Avi-tagged/Tev-fused human MEK1 expressed in Escherichia coli in absence of AMP-PNP by SPR assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00563 BindingDB Entry DOI: 10.7270/Q2PZ5DF5
					More data for this Ligand-Target Pair