Found 9 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
DNA primase
(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50013091
(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)Show InChI InChI=1S/C11H7Cl2N5O/c12-6-2-1-5(3-7(6)13)16-11-17-9-8(10(19)18-11)14-4-15-9/h1-4H,(H3,14,15,16,17,18,19) | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School
Curated by ChEMBL
| Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells |
J Med Chem 38: 1820-5 (1995)
BindingDB Entry DOI: 10.7270/Q29K4983 |
More data for this Ligand-Target Pair | |
Thymidine kinase
(Human herpesvirus 1 (strain SC16) (HHV-1) (Human h...) | BDBM50013091
(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)Show InChI InChI=1S/C11H7Cl2N5O/c12-6-2-1-5(3-7(6)13)16-11-17-9-8(10(19)18-11)14-4-15-9/h1-4H,(H3,14,15,16,17,18,19) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Massachusetts Medical School
Curated by ChEMBL
| Assay Description Inhibition of TdR phosphorylation using thymidine kinase assay for herpes simplex virus type 2 |
J Med Chem 33: 203-6 (1990)
BindingDB Entry DOI: 10.7270/Q2B8573M |
More data for this Ligand-Target Pair | |
Thymidine kinase
(Human herpesvirus 2) | BDBM50013091
(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)Show InChI InChI=1S/C11H7Cl2N5O/c12-6-2-1-5(3-7(6)13)16-11-17-9-8(10(19)18-11)14-4-15-9/h1-4H,(H3,14,15,16,17,18,19) | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 3.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Massachusetts Medical School
Curated by ChEMBL
| Assay Description Inhibitory activity against HSV-2 thymidine kinase isolated from HeLa cells |
J Med Chem 35: 2979-83 (1992)
BindingDB Entry DOI: 10.7270/Q29G5Q2Q |
More data for this Ligand-Target Pair | |
DNA polymerase alpha catalytic subunit
(Homo sapiens (Human)) | BDBM50013091
(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)Show InChI InChI=1S/C11H7Cl2N5O/c12-6-2-1-5(3-7(6)13)16-11-17-9-8(10(19)18-11)14-4-15-9/h1-4H,(H3,14,15,16,17,18,19) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 4.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School
Curated by ChEMBL
| Assay Description Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrate |
J Med Chem 38: 1820-5 (1995)
BindingDB Entry DOI: 10.7270/Q29K4983 |
More data for this Ligand-Target Pair | |
DNA polymerase alpha catalytic subunit
(Homo sapiens (Human)) | BDBM50013091
(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)Show InChI InChI=1S/C11H7Cl2N5O/c12-6-2-1-5(3-7(6)13)16-11-17-9-8(10(19)18-11)14-4-15-9/h1-4H,(H3,14,15,16,17,18,19) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 4.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School
Curated by ChEMBL
| Assay Description Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrate |
J Med Chem 38: 1820-5 (1995)
BindingDB Entry DOI: 10.7270/Q29K4983 |
More data for this Ligand-Target Pair | |
DNA primase
(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50013091
(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)Show InChI InChI=1S/C11H7Cl2N5O/c12-6-2-1-5(3-7(6)13)16-11-17-9-8(10(19)18-11)14-4-15-9/h1-4H,(H3,14,15,16,17,18,19) | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 5.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School
Curated by ChEMBL
| Assay Description Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primase |
J Med Chem 38: 1820-5 (1995)
BindingDB Entry DOI: 10.7270/Q29K4983 |
More data for this Ligand-Target Pair | |
Thymidine kinase
(Human herpesvirus 1 (strain SC16) (HHV-1) (Human h...) | BDBM50013091
(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)Show InChI InChI=1S/C11H7Cl2N5O/c12-6-2-1-5(3-7(6)13)16-11-17-9-8(10(19)18-11)14-4-15-9/h1-4H,(H3,14,15,16,17,18,19) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Massachusetts Medical School
Curated by ChEMBL
| Assay Description Inhibitory activity against HSV-1 thymidine kinase isolated from HeLa cells |
J Med Chem 35: 2979-83 (1992)
BindingDB Entry DOI: 10.7270/Q29G5Q2Q |
More data for this Ligand-Target Pair | |
Thymidine kinase
(Human herpesvirus 1) | BDBM50013091
(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)Show InChI InChI=1S/C11H7Cl2N5O/c12-6-2-1-5(3-7(6)13)16-11-17-9-8(10(19)18-11)14-4-15-9/h1-4H,(H3,14,15,16,17,18,19) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Massachusetts Medical School
Curated by ChEMBL
| Assay Description Inhibition of TdR phosphorylation using thymidine kinase assay for herpes simplex virus type 1 |
J Med Chem 33: 203-6 (1990)
BindingDB Entry DOI: 10.7270/Q2B8573M |
More data for this Ligand-Target Pair | |
DNA topoisomerase 1
(Homo sapiens (Human)) | BDBM50013091
(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)Show InChI InChI=1S/C11H7Cl2N5O/c12-6-2-1-5(3-7(6)13)16-11-17-9-8(10(19)18-11)14-4-15-9/h1-4H,(H3,14,15,16,17,18,19) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School
Curated by ChEMBL
| Assay Description Inhibition against DNA topoisomerase I by direct assay with activated DNA and 25 uM dNTPs including [3H]-dTTP |
J Med Chem 38: 1820-5 (1995)
BindingDB Entry DOI: 10.7270/Q29K4983 |
More data for this Ligand-Target Pair | |