Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 391.8 BDBM50341094

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuromedin-K receptor (Homo sapiens (Human))	BDBM50341094 (2-(4-(3-(4-chlorophenyl)-1H-pyrazole-5-carbonyl)pi...) Show SMILES Clc1ccc(cc1)-c1cc([nH]n1)C(=O)N1CCN(CC1)c1ccccc1C#N Show InChI InChI=1S/C21H18ClN5O/c22-17-7-5-15(6-8-17)18-13-19(25-24-18)21(28)27-11-9-26(10-12-27)20-4-2-1-3-16(20)14-23/h1-8,13H,9-12H2,(H,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Euroscreen SA Curated by ChEMBL					Assay Description Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...				Bioorg Med Chem Lett 21: 1991-6 (2011) Article DOI: 10.1016/j.bmcl.2011.02.033 BindingDB Entry DOI: 10.7270/Q2B56K16
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