Found 8 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393889
(US10597367, Example 186 | US9969726, Example 186)Show SMILES Clc1ccc(cc1)-c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:12| Show InChI InChI=1S/C20H13Cl2N3O/c21-15-4-1-12(2-5-15)13-3-6-16-18(9-13)25-20(26)11-17(24-16)14-7-8-23-19(22)10-14/h1-10H,11H2,(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.42E+3 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393889
(US10597367, Example 186 | US9969726, Example 186)Show SMILES Clc1ccc(cc1)-c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:12| Show InChI InChI=1S/C20H13Cl2N3O/c21-15-4-1-12(2-5-15)13-3-6-16-18(9-13)25-20(26)11-17(24-16)14-7-8-23-19(22)10-14/h1-10H,11H2,(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.01E+3 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM393889
(US10597367, Example 186 | US9969726, Example 186)Show SMILES Clc1ccc(cc1)-c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:12| Show InChI InChI=1S/C20H13Cl2N3O/c21-15-4-1-12(2-5-15)13-3-6-16-18(9-13)25-20(26)11-17(24-16)14-7-8-23-19(22)10-14/h1-10H,11H2,(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.36E+3 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM393889
(US10597367, Example 186 | US9969726, Example 186)Show SMILES Clc1ccc(cc1)-c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:12| Show InChI InChI=1S/C20H13Cl2N3O/c21-15-4-1-12(2-5-15)13-3-6-16-18(9-13)25-20(26)11-17(24-16)14-7-8-23-19(22)10-14/h1-10H,11H2,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.25E+3 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393889
(US10597367, Example 186 | US9969726, Example 186)Show SMILES Clc1ccc(cc1)-c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:12| Show InChI InChI=1S/C20H13Cl2N3O/c21-15-4-1-12(2-5-15)13-3-6-16-18(9-13)25-20(26)11-17(24-16)14-7-8-23-19(22)10-14/h1-10H,11H2,(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.42E+3 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393889
(US10597367, Example 186 | US9969726, Example 186)Show SMILES Clc1ccc(cc1)-c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:12| Show InChI InChI=1S/C20H13Cl2N3O/c21-15-4-1-12(2-5-15)13-3-6-16-18(9-13)25-20(26)11-17(24-16)14-7-8-23-19(22)10-14/h1-10H,11H2,(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.01E+3 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM393889
(US10597367, Example 186 | US9969726, Example 186)Show SMILES Clc1ccc(cc1)-c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:12| Show InChI InChI=1S/C20H13Cl2N3O/c21-15-4-1-12(2-5-15)13-3-6-16-18(9-13)25-20(26)11-17(24-16)14-7-8-23-19(22)10-14/h1-10H,11H2,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.36E+3 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM393889
(US10597367, Example 186 | US9969726, Example 186)Show SMILES Clc1ccc(cc1)-c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:12| Show InChI InChI=1S/C20H13Cl2N3O/c21-15-4-1-12(2-5-15)13-3-6-16-18(9-13)25-20(26)11-17(24-16)14-7-8-23-19(22)10-14/h1-10H,11H2,(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.25E+3 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |