Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cytochrome P450 11B2, mitochondrial
(Homo sapiens (Human)) | BDBM50425466
(CHEMBL2312961)Show SMILES Clc1ccc(cc1)C(c1ccncc1)c1cc2CCN3c2c(CCC3=O)c1 Show InChI InChI=1S/C23H19ClN2O/c24-20-4-1-15(2-5-20)22(16-7-10-25-11-8-16)19-13-17-3-6-21(27)26-12-9-18(14-19)23(17)26/h1-2,4-5,7-8,10-11,13-14,22H,3,6,9,12H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University& Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
Curated by ChEMBL
| Assay Description Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxy-corticosterone as substrate |
J Med Chem 56: 460-70 (2013)
Article DOI: 10.1021/jm301408t BindingDB Entry DOI: 10.7270/Q2X34ZSF |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM50425466
(CHEMBL2312961)Show SMILES Clc1ccc(cc1)C(c1ccncc1)c1cc2CCN3c2c(CCC3=O)c1 Show InChI InChI=1S/C23H19ClN2O/c24-20-4-1-15(2-5-20)22(16-7-10-25-11-8-16)19-13-17-3-6-21(27)26-12-9-18(14-19)23(17)26/h1-2,4-5,7-8,10-11,13-14,22H,3,6,9,12H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University& Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
Curated by ChEMBL
| Assay Description Inhibition of human CYP19 using [1beta-3H]androstenedione as substrate by 3H2O method |
J Med Chem 56: 460-70 (2013)
Article DOI: 10.1021/jm301408t BindingDB Entry DOI: 10.7270/Q2X34ZSF |
More data for this Ligand-Target Pair | |
Cytochrome P450 11B1, mitochondrial
(Homo sapiens (Human)) | BDBM50425466
(CHEMBL2312961)Show SMILES Clc1ccc(cc1)C(c1ccncc1)c1cc2CCN3c2c(CCC3=O)c1 Show InChI InChI=1S/C23H19ClN2O/c24-20-4-1-15(2-5-20)22(16-7-10-25-11-8-16)19-13-17-3-6-21(27)26-12-9-18(14-19)23(17)26/h1-2,4-5,7-8,10-11,13-14,22H,3,6,9,12H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University& Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
Curated by ChEMBL
| Assay Description Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxy-corticosterone as substrate |
J Med Chem 56: 460-70 (2013)
Article DOI: 10.1021/jm301408t BindingDB Entry DOI: 10.7270/Q2X34ZSF |
More data for this Ligand-Target Pair | |