Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 334.5 BDBM50311876

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50311876 (CHEMBL1075626 | N-(3-bromophenyl)-6-chloroquinazol...) Show SMILES Clc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 Show InChI InChI=1S/C14H9BrClN3/c15-9-2-1-3-11(6-9)19-14-12-7-10(16)4-5-13(12)17-8-18-14/h1-8H,(H,17,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	249	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Displacement of [3H]3methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGluR5				Bioorg Med Chem Lett 19: 6623-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.024 BindingDB Entry DOI: 10.7270/Q2TX3FHM
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50311876 (CHEMBL1075626 | N-(3-bromophenyl)-6-chloroquinazol...) Show SMILES Clc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 Show InChI InChI=1S/C14H9BrClN3/c15-9-2-1-3-11(6-9)19-14-12-7-10(16)4-5-13(12)17-8-18-14/h1-8H,(H,17,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in HEK293 cells by calcium mobilization assay				Bioorg Med Chem Lett 19: 6623-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.024 BindingDB Entry DOI: 10.7270/Q2TX3FHM
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50311876 (CHEMBL1075626 | N-(3-bromophenyl)-6-chloroquinazol...) Show SMILES Clc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 Show InChI InChI=1S/C14H9BrClN3/c15-9-2-1-3-11(6-9)19-14-12-7-10(16)4-5-13(12)17-8-18-14/h1-8H,(H,17,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	955	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1 expressed in BHK cells by calcium mobilization assay				Bioorg Med Chem Lett 19: 6623-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.024 BindingDB Entry DOI: 10.7270/Q2TX3FHM
					More data for this Ligand-Target Pair