Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Proline-rich AKT1 substrate 1
(Homo sapiens (Human)) | BDBM386039
(4-(4-(1-(2-chlorophenyl)-2-(pyrrolidin-1-yl)ethyl)...)Show SMILES Clc1ccccc1C(CN1CCCC1)N1CCN(CC1)c1ncnc2NCC(=O)Nc12 Show InChI InChI=1S/C22H28ClN7O/c23-17-6-2-1-5-16(17)18(14-28-7-3-4-8-28)29-9-11-30(12-10-29)22-20-21(25-15-26-22)24-13-19(31)27-20/h1-2,5-6,15,18H,3-4,7-14H2,(H,27,31)(H,24,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description
A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1 [T412E]
(Homo sapiens (Human)) | BDBM386039
(4-(4-(1-(2-chlorophenyl)-2-(pyrrolidin-1-yl)ethyl)...)Show SMILES Clc1ccccc1C(CN1CCCC1)N1CCN(CC1)c1ncnc2NCC(=O)Nc12 Show InChI InChI=1S/C22H28ClN7O/c23-17-6-2-1-5-16(17)18(14-28-7-3-4-8-28)29-9-11-30(12-10-29)22-20-21(25-15-26-22)24-13-19(31)27-20/h1-2,5-6,15,18H,3-4,7-14H2,(H,27,31)(H,24,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this
Ligand-Target Pair | |