Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50446148
(CHEMBL3109005 | US9518026, Example 33 | US9956214,...)Show SMILES Cn1c(N)nc2cc(ccc12)-c1nn(c(N)c1C(N)=O)C(C)(C)C Show InChI InChI=1S/C16H21N7O/c1-16(2,3)23-13(17)11(14(18)24)12(21-23)8-5-6-10-9(7-8)20-15(19)22(10)4/h5-7H,17H2,1-4H3,(H2,18,24)(H2,19,20) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50446148
(CHEMBL3109005 | US9518026, Example 33 | US9956214,...)Show SMILES Cn1c(N)nc2cc(ccc12)-c1nn(c(N)c1C(N)=O)C(C)(C)C Show InChI InChI=1S/C16H21N7O/c1-16(2,3)23-13(17)11(14(18)24)12(21-23)8-5-6-10-9(7-8)20-15(19)22(10)4/h5-7H,17H2,1-4H3,(H2,18,24)(H2,19,20) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50446148
(CHEMBL3109005 | US9518026, Example 33 | US9956214,...)Show SMILES Cn1c(N)nc2cc(ccc12)-c1nn(c(N)c1C(N)=O)C(C)(C)C Show InChI InChI=1S/C16H21N7O/c1-16(2,3)23-13(17)11(14(18)24)12(21-23)8-5-6-10-9(7-8)20-15(19)22(10)4/h5-7H,17H2,1-4H3,(H2,18,24)(H2,19,20) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrate |
ACS Med Chem Lett 5: 40-44 (2014)
Article DOI: 10.1021/ml400315s BindingDB Entry DOI: 10.7270/Q28917BZ |
More data for this Ligand-Target Pair | |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM50446148
(CHEMBL3109005 | US9518026, Example 33 | US9956214,...)Show SMILES Cn1c(N)nc2cc(ccc12)-c1nn(c(N)c1C(N)=O)C(C)(C)C Show InChI InChI=1S/C16H21N7O/c1-16(2,3)23-13(17)11(14(18)24)12(21-23)8-5-6-10-9(7-8)20-15(19)22(10)4/h5-7H,17H2,1-4H3,(H2,18,24)(H2,19,20) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Uncharacterized protein
(Cryptosporidium parvum) | BDBM50446148
(CHEMBL3109005 | US9518026, Example 33 | US9956214,...)Show SMILES Cn1c(N)nc2cc(ccc12)-c1nn(c(N)c1C(N)=O)C(C)(C)C Show InChI InChI=1S/C16H21N7O/c1-16(2,3)23-13(17)11(14(18)24)12(21-23)8-5-6-10-9(7-8)20-15(19)22(10)4/h5-7H,17H2,1-4H3,(H2,18,24)(H2,19,20) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |