Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
(Homo sapiens (Human)) | BDBM50054401
(CHEMBL3319362 | US9522881, 11a-7 (L97M93) | US9844...)Show SMILES Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)N2CCc3cc(Br)ccc23)c1 Show InChI InChI=1S/C26H19BrIN3O5/c1-30-20-12-21(32)18(26(35)36)11-17(20)22(28)23(30)14-3-2-4-16(10-14)29-24(33)25(34)31-8-7-13-9-15(27)5-6-19(13)31/h2-6,9-12,32H,7-8H2,1H3,(H,29,33)(H,35,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University Research and Technology Corporation
US Patent
| Assay Description The inhibition assays were performed at 25° C. in 50 mM 3,3-dimethylglutarate buffer, pH 7.0, containing 1 mM EDTA with an ionic strength of 0.15M ad... |
US Patent US9522881 (2016)
BindingDB Entry DOI: 10.7270/Q2DN4402 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
(Homo sapiens (Human)) | BDBM50054401
(CHEMBL3319362 | US9522881, 11a-7 (L97M93) | US9844...)Show SMILES Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)N2CCc3cc(Br)ccc23)c1 Show InChI InChI=1S/C26H19BrIN3O5/c1-30-20-12-21(32)18(26(35)36)11-17(20)22(28)23(30)14-3-2-4-16(10-14)29-24(33)25(34)31-8-7-13-9-15(27)5-6-19(13)31/h2-6,9-12,32H,7-8H2,1H3,(H,29,33)(H,35,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| Assay Description PTP assays were conducted as previously described in Kontaridis et al., J Biol Chem. 2006; 281:6785-6792, using para-nitrophenyl phosphate (pNPP, obt... |
US Patent US9844535 (2017)
BindingDB Entry DOI: 10.7270/Q2NZ89X1 |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 11
(Homo sapiens (Human)) | BDBM50054401
(CHEMBL3319362 | US9522881, 11a-7 (L97M93) | US9844...)Show SMILES Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)N2CCc3cc(Br)ccc23)c1 Show InChI InChI=1S/C26H19BrIN3O5/c1-30-20-12-21(32)18(26(35)36)11-17(20)22(28)23(30)14-3-2-4-16(10-14)29-24(33)25(34)31-8-7-13-9-15(27)5-6-19(13)31/h2-6,9-12,32H,7-8H2,1H3,(H,29,33)(H,35,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of SHP2 (unknown origin) using p-nitrophenyl phosphate substrate by microplate spectrophotometry |
J Med Chem 57: 6594-609 (2014)
Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM |
More data for this Ligand-Target Pair | |