Found 6 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glycogen synthase kinase-3 beta
(Rattus norvegicus (rat)) | BDBM7283
(14-bromo-18-methyl-8,18-diazatetracyclo[9.7.0.0^{2...)Show InChI InChI=1S/C17H13BrN2O/c1-20-15-7-6-10(18)8-12(15)13-9-16(21)19-14-5-3-2-4-11(14)17(13)20/h2-8H,9H2,1H3,(H,19,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | 30 |
CNRS
| Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P... |
Eur J Biochem 267: 5983-94 (2000)
Article DOI: 10.1046/j.1432-1327.2000.01673.x BindingDB Entry DOI: 10.7270/Q2CR5RJS |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM7283
(14-bromo-18-methyl-8,18-diazatetracyclo[9.7.0.0^{2...)Show InChI InChI=1S/C17H13BrN2O/c1-20-15-7-6-10(18)8-12(15)13-9-16(21)19-14-5-3-2-4-11(14)17(13)20/h2-8H,9H2,1H3,(H,19,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t Braunschweig
Curated by ChEMBL
| Assay Description Inhibition of GSK3-beta expressed in insect Sf9 cells |
Eur J Med Chem 45: 335-42 (2010)
Article DOI: 10.1016/j.ejmech.2009.10.018 BindingDB Entry DOI: 10.7270/Q26W9C1V |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3
(Homo sapiens (Human)) | BDBM7283
(14-bromo-18-methyl-8,18-diazatetracyclo[9.7.0.0^{2...)Show InChI InChI=1S/C17H13BrN2O/c1-20-15-7-6-10(18)8-12(15)13-9-16(21)19-14-5-3-2-4-11(14)17(13)20/h2-8H,9H2,1H3,(H,19,21) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t Braunschweig
Curated by ChEMBL
| Assay Description Inhibition of CDK1/cyclin B expressed in M phase starfish oocyte |
Eur J Med Chem 45: 335-42 (2010)
Article DOI: 10.1016/j.ejmech.2009.10.018 BindingDB Entry DOI: 10.7270/Q26W9C1V |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM7283
(14-bromo-18-methyl-8,18-diazatetracyclo[9.7.0.0^{2...)Show InChI InChI=1S/C17H13BrN2O/c1-20-15-7-6-10(18)8-12(15)13-9-16(21)19-14-5-3-2-4-11(14)17(13)20/h2-8H,9H2,1H3,(H,19,21) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Hamburg
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against cyclin-dependent kinase 1-cyclin B (Cyclin-Dependent Kinase) harvested from starfish oocytes. |
J Med Chem 42: 2909-19 (1999)
Article DOI: 10.1021/jm9900570 BindingDB Entry DOI: 10.7270/Q21C1W2R |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B
(Marthasterias glacialis (starfish)) | BDBM7283
(14-bromo-18-methyl-8,18-diazatetracyclo[9.7.0.0^{2...)Show InChI InChI=1S/C17H13BrN2O/c1-20-15-7-6-10(18)8-12(15)13-9-16(21)19-14-5-3-2-4-11(14)17(13)20/h2-8H,9H2,1H3,(H,19,21) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | 30 |
CNRS
| Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P... |
Eur J Biochem 267: 5983-94 (2000)
Article DOI: 10.1046/j.1432-1327.2000.01673.x BindingDB Entry DOI: 10.7270/Q2CR5RJS |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 5 activator 1 [99-307]
(Homo sapiens (Human)) | BDBM7283
(14-bromo-18-methyl-8,18-diazatetracyclo[9.7.0.0^{2...)Show InChI InChI=1S/C17H13BrN2O/c1-20-15-7-6-10(18)8-12(15)13-9-16(21)19-14-5-3-2-4-11(14)17(13)20/h2-8H,9H2,1H3,(H,19,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.00E+5 | n/a | n/a | n/a | n/a | n/a | 30 |
CNRS
| Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P... |
Eur J Biochem 267: 5983-94 (2000)
Article DOI: 10.1046/j.1432-1327.2000.01673.x BindingDB Entry DOI: 10.7270/Q2CR5RJS |
More data for this Ligand-Target Pair | |