Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
DNA polymerase catalytic subunit
(Human cytomegalovirus (HCMV strain AD169) ) | BDBM50172518
(2-(3-Hydroxy-propyl)-7-methyl-4-oxo-4,7-dihydro-th...)Show SMILES Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCCO)sc12 Show InChI InChI=1S/C19H19ClN2O3S/c1-22-11-16(18(25)21-10-12-4-6-13(20)7-5-12)17(24)15-9-14(3-2-8-23)26-19(15)22/h4-7,9,11,23H,2-3,8,10H2,1H3,(H,21,25) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pharmacia Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 d... |
J Med Chem 48: 5794-804 (2005)
Article DOI: 10.1021/jm050162b
BindingDB Entry DOI: 10.7270/Q2G44R39 |
More data for this
Ligand-Target Pair | |
DNA polymerase catalytic subunit
(Varicella-zoster virus (strain Dumas) (HHV-3) (Hum...) | BDBM50172518
(2-(3-Hydroxy-propyl)-7-methyl-4-oxo-4,7-dihydro-th...)Show SMILES Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCCO)sc12 Show InChI InChI=1S/C19H19ClN2O3S/c1-22-11-16(18(25)21-10-12-4-6-13(20)7-5-12)17(24)15-9-14(3-2-8-23)26-19(15)22/h4-7,9,11,23H,2-3,8,10H2,1H3,(H,21,25) | UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pharmacia Corporation
Curated by ChEMBL
| Assay Description
Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 ... |
J Med Chem 48: 5794-804 (2005)
Article DOI: 10.1021/jm050162b
BindingDB Entry DOI: 10.7270/Q2G44R39 |
More data for this
Ligand-Target Pair | |
DNA polymerase catalytic subunit
(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50172518
(2-(3-Hydroxy-propyl)-7-methyl-4-oxo-4,7-dihydro-th...)Show SMILES Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCCO)sc12 Show InChI InChI=1S/C19H19ClN2O3S/c1-22-11-16(18(25)21-10-12-4-6-13(20)7-5-12)17(24)15-9-14(3-2-8-23)26-19(15)22/h4-7,9,11,23H,2-3,8,10H2,1H3,(H,21,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pharmacia Corporation
Curated by ChEMBL
| Assay Description
Inhibition of herpes simplex virus type 1 DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes a... |
J Med Chem 48: 5794-804 (2005)
Article DOI: 10.1021/jm050162b
BindingDB Entry DOI: 10.7270/Q2G44R39 |
More data for this
Ligand-Target Pair | |
DNA polymerase alpha catalytic subunit
(Homo sapiens (Human)) | BDBM50172518
(2-(3-Hydroxy-propyl)-7-methyl-4-oxo-4,7-dihydro-th...)Show SMILES Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCCO)sc12 Show InChI InChI=1S/C19H19ClN2O3S/c1-22-11-16(18(25)21-10-12-4-6-13(20)7-5-12)17(24)15-9-14(3-2-8-23)26-19(15)22/h4-7,9,11,23H,2-3,8,10H2,1H3,(H,21,25) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pharmacia Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C... |
J Med Chem 48: 5794-804 (2005)
Article DOI: 10.1021/jm050162b
BindingDB Entry DOI: 10.7270/Q2G44R39 |
More data for this
Ligand-Target Pair | |