Found 7 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
DNA polymerase catalytic subunit
(Varicella-zoster virus (strain Dumas) (HHV-3) (Hum...) | BDBM50172514
(7-Methyl-2-morpholin-4-ylmethyl-4-oxo-4,7-dihydro-...)Show SMILES Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN3CCOCC3)sc12 Show InChI InChI=1S/C21H22ClN3O3S/c1-24-13-18(20(27)23-11-14-2-4-15(22)5-3-14)19(26)17-10-16(29-21(17)24)12-25-6-8-28-9-7-25/h2-5,10,13H,6-9,11-12H2,1H3,(H,23,27) | UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 770 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pharmacia Corporation
Curated by ChEMBL
| Assay Description
Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 ... |
J Med Chem 48: 5794-804 (2005)
Article DOI: 10.1021/jm050162b
BindingDB Entry DOI: 10.7270/Q2G44R39 |
More data for this
Ligand-Target Pair | |
DNA polymerase catalytic subunit
(Human cytomegalovirus (HCMV strain AD169) ) | BDBM50172514
(7-Methyl-2-morpholin-4-ylmethyl-4-oxo-4,7-dihydro-...)Show SMILES Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN3CCOCC3)sc12 Show InChI InChI=1S/C21H22ClN3O3S/c1-24-13-18(20(27)23-11-14-2-4-15(22)5-3-14)19(26)17-10-16(29-21(17)24)12-25-6-8-28-9-7-25/h2-5,10,13H,6-9,11-12H2,1H3,(H,23,27) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pharmacia Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 d... |
J Med Chem 48: 5794-804 (2005)
Article DOI: 10.1021/jm050162b
BindingDB Entry DOI: 10.7270/Q2G44R39 |
More data for this
Ligand-Target Pair | |
DNA polymerase catalytic subunit
(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50172514
(7-Methyl-2-morpholin-4-ylmethyl-4-oxo-4,7-dihydro-...)Show SMILES Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN3CCOCC3)sc12 Show InChI InChI=1S/C21H22ClN3O3S/c1-24-13-18(20(27)23-11-14-2-4-15(22)5-3-14)19(26)17-10-16(29-21(17)24)12-25-6-8-28-9-7-25/h2-5,10,13H,6-9,11-12H2,1H3,(H,23,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pharmacia Corporation
Curated by ChEMBL
| Assay Description
Inhibition of herpes simplex virus type 1 DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes a... |
J Med Chem 48: 5794-804 (2005)
Article DOI: 10.1021/jm050162b
BindingDB Entry DOI: 10.7270/Q2G44R39 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50172514
(7-Methyl-2-morpholin-4-ylmethyl-4-oxo-4,7-dihydro-...)Show SMILES Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN3CCOCC3)sc12 Show InChI InChI=1S/C21H22ClN3O3S/c1-24-13-18(20(27)23-11-14-2-4-15(22)5-3-14)19(26)17-10-16(29-21(17)24)12-25-6-8-28-9-7-25/h2-5,10,13H,6-9,11-12H2,1H3,(H,23,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| | n/a | n/a | 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
DNA polymerase delta catalytic subunit
(Homo sapiens (Human)) | BDBM50172514
(7-Methyl-2-morpholin-4-ylmethyl-4-oxo-4,7-dihydro-...)Show SMILES Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN3CCOCC3)sc12 Show InChI InChI=1S/C21H22ClN3O3S/c1-24-13-18(20(27)23-11-14-2-4-15(22)5-3-14)19(26)17-10-16(29-21(17)24)12-25-6-8-28-9-7-25/h2-5,10,13H,6-9,11-12H2,1H3,(H,23,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pharmacia Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human delta DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C... |
J Med Chem 48: 5794-804 (2005)
Article DOI: 10.1021/jm050162b
BindingDB Entry DOI: 10.7270/Q2G44R39 |
More data for this
Ligand-Target Pair | |
DNA polymerase alpha catalytic subunit
(Homo sapiens (Human)) | BDBM50172514
(7-Methyl-2-morpholin-4-ylmethyl-4-oxo-4,7-dihydro-...)Show SMILES Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN3CCOCC3)sc12 Show InChI InChI=1S/C21H22ClN3O3S/c1-24-13-18(20(27)23-11-14-2-4-15(22)5-3-14)19(26)17-10-16(29-21(17)24)12-25-6-8-28-9-7-25/h2-5,10,13H,6-9,11-12H2,1H3,(H,23,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pharmacia Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C... |
J Med Chem 48: 5794-804 (2005)
Article DOI: 10.1021/jm050162b
BindingDB Entry DOI: 10.7270/Q2G44R39 |
More data for this
Ligand-Target Pair | |
DNA polymerase catalytic subunit
(Varicella-zoster virus (strain Dumas) (HHV-3) (Hum...) | BDBM50172514
(7-Methyl-2-morpholin-4-ylmethyl-4-oxo-4,7-dihydro-...)Show SMILES Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN3CCOCC3)sc12 Show InChI InChI=1S/C21H22ClN3O3S/c1-24-13-18(20(27)23-11-14-2-4-15(22)5-3-14)19(26)17-10-16(29-21(17)24)12-25-6-8-28-9-7-25/h2-5,10,13H,6-9,11-12H2,1H3,(H,23,27) | UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pharmacia Corporation
Curated by ChEMBL
| Assay Description
Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 ... |
J Med Chem 48: 5794-804 (2005)
Article DOI: 10.1021/jm050162b
BindingDB Entry DOI: 10.7270/Q2G44R39 |
More data for this
Ligand-Target Pair | |