Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50512916
(CHEMBL4463314)Show SMILES Cn1cc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)c2ccc(cc2)-c2cc[nH]n2)c(n1)C(F)(F)F |r| Show InChI InChI=1S/C22H22F3N5O2/c1-30-12-18(20(29-30)22(23,24)25)27-21(32)16-5-3-2-4-15(16)19(31)14-8-6-13(7-9-14)17-10-11-26-28-17/h6-12,15-16H,2-5H2,1H3,(H,26,28)(H,27,32)/t15-,16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by scintillation counting method |
J Med Chem 62: 4325-4349 (2019)
Article DOI: 10.1021/acs.jmedchem.8b02012 BindingDB Entry DOI: 10.7270/Q2S75KP2 |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50512916
(CHEMBL4463314)Show SMILES Cn1cc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)c2ccc(cc2)-c2cc[nH]n2)c(n1)C(F)(F)F |r| Show InChI InChI=1S/C22H22F3N5O2/c1-30-12-18(20(29-30)22(23,24)25)27-21(32)16-5-3-2-4-15(16)19(31)14-8-6-13(7-9-14)17-10-11-26-28-17/h6-12,15-16H,2-5H2,1H3,(H,26,28)(H,27,32)/t15-,16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human whole blood assessed as reduction in calcium ionophore-stimulated LTB4 production preincubated for 30 mins followed by ca... |
J Med Chem 62: 4325-4349 (2019)
Article DOI: 10.1021/acs.jmedchem.8b02012 BindingDB Entry DOI: 10.7270/Q2S75KP2 |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50512916
(CHEMBL4463314)Show SMILES Cn1cc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)c2ccc(cc2)-c2cc[nH]n2)c(n1)C(F)(F)F |r| Show InChI InChI=1S/C22H22F3N5O2/c1-30-12-18(20(29-30)22(23,24)25)27-21(32)16-5-3-2-4-15(16)19(31)14-8-6-13(7-9-14)17-10-11-26-28-17/h6-12,15-16H,2-5H2,1H3,(H,26,28)(H,27,32)/t15-,16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of recombinant human CYP3A4 expressed in Escherichia coli assessed as maximum reduction in metabolite formation using coumarin based subst... |
J Med Chem 62: 4325-4349 (2019)
Article DOI: 10.1021/acs.jmedchem.8b02012 BindingDB Entry DOI: 10.7270/Q2S75KP2 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50512916
(CHEMBL4463314)Show SMILES Cn1cc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)c2ccc(cc2)-c2cc[nH]n2)c(n1)C(F)(F)F |r| Show InChI InChI=1S/C22H22F3N5O2/c1-30-12-18(20(29-30)22(23,24)25)27-21(32)16-5-3-2-4-15(16)19(31)14-8-6-13(7-9-14)17-10-11-26-28-17/h6-12,15-16H,2-5H2,1H3,(H,26,28)(H,27,32)/t15-,16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of human ERG by high-throughput electrophysiology assay |
J Med Chem 62: 4325-4349 (2019)
Article DOI: 10.1021/acs.jmedchem.8b02012 BindingDB Entry DOI: 10.7270/Q2S75KP2 |
More data for this Ligand-Target Pair | |