Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50448686
(CHEMBL3127658 | US9102669, 3)Show SMILES Cn1cc(cn1)-c1ccc(nn1)N1CCC(CC1)n1ccc2ccccc12 Show InChI InChI=1S/C21H22N6/c1-25-15-17(14-22-25)19-6-7-21(24-23-19)26-11-9-18(10-12-26)27-13-8-16-4-2-3-5-20(16)27/h2-8,13-15,18H,9-12H2,1H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | 25 |
Janssen Pharmaceutica NV
US Patent
| Assay Description The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e... |
US Patent US9102669 (2015)
BindingDB Entry DOI: 10.7270/Q2BC3X9V |
More data for this Ligand-Target Pair | |
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50448686
(CHEMBL3127658 | US9102669, 3)Show SMILES Cn1cc(cn1)-c1ccc(nn1)N1CCC(CC1)n1ccc2ccccc12 Show InChI InChI=1S/C21H22N6/c1-25-15-17(14-22-25)19-6-7-21(24-23-19)26-11-9-18(10-12-26)27-13-8-16-4-2-3-5-20(16)27/h2-8,13-15,18H,9-12H2,1H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 422 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description Inhibition of SCD1 in Sprague-Dawley rat liver microsomes using stearoyl-[9,10-3H]-CoA as substrate |
Bioorg Med Chem Lett 24: 1437-41 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.075 BindingDB Entry DOI: 10.7270/Q26M38BM |
More data for this Ligand-Target Pair | |