Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM286236
(Compound 1460 | US9518026, Example 29 | US9956214,...)Show SMILES Cn1nc(N)c2ccc(cc12)-c1nn(cc1C(N)=O)C(C)(C)C Show InChI InChI=1S/C16H20N6O/c1-16(2,3)22-8-11(15(18)23)13(19-22)9-5-6-10-12(7-9)21(4)20-14(10)17/h5-8H,1-4H3,(H2,17,20)(H2,18,23) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM286236
(Compound 1460 | US9518026, Example 29 | US9956214,...)Show SMILES Cn1nc(N)c2ccc(cc12)-c1nn(cc1C(N)=O)C(C)(C)C Show InChI InChI=1S/C16H20N6O/c1-16(2,3)22-8-11(15(18)23)13(19-22)9-5-6-10-12(7-9)21(4)20-14(10)17/h5-8H,1-4H3,(H2,17,20)(H2,18,23) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM286236
(Compound 1460 | US9518026, Example 29 | US9956214,...)Show SMILES Cn1nc(N)c2ccc(cc12)-c1nn(cc1C(N)=O)C(C)(C)C Show InChI InChI=1S/C16H20N6O/c1-16(2,3)22-8-11(15(18)23)13(19-22)9-5-6-10-12(7-9)21(4)20-14(10)17/h5-8H,1-4H3,(H2,17,20)(H2,18,23) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Uncharacterized protein
(Cryptosporidium parvum) | BDBM286236
(Compound 1460 | US9518026, Example 29 | US9956214,...)Show SMILES Cn1nc(N)c2ccc(cc12)-c1nn(cc1C(N)=O)C(C)(C)C Show InChI InChI=1S/C16H20N6O/c1-16(2,3)22-8-11(15(18)23)13(19-22)9-5-6-10-12(7-9)21(4)20-14(10)17/h5-8H,1-4H3,(H2,17,20)(H2,18,23) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |