Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 358.3 BDBM50539014

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539014 (CHEMBL4636668) Show SMILES Cn1nnc2ccc(C(=O)NC3CN(C3)c3ccc(F)c(F)c3)c(N)c12 Show InChI InChI=1S/C17H16F2N6O/c1-24-16-14(22-23-24)5-3-11(15(16)20)17(26)21-9-7-25(8-9)10-2-4-12(18)13(19)6-10/h2-6,9H,7-8,20H2,1H3,(H,21,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.43E+3	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair