Found 6 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 8
(Homo sapiens (Human)) | BDBM50352626
(CHEMBL1822307 | US9796706, Compound 131)Show SMILES FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-c3ncco3)c(=O)ccc2c1 Show InChI InChI=1S/C20H11F3N4O3S/c21-20(22,23)13-2-3-14-11(7-13)1-4-16(29)27(14)9-15(28)26-19-17(12(8-24)10-31-19)18-25-5-6-30-18/h1-7,10H,9H2,(H,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of recombinant JNK1 using ser73 of c-jun as substrate preincubated for 15 mins measured after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 21: 5521-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.100 BindingDB Entry DOI: 10.7270/Q29Z959K |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 10
(Homo sapiens (Human)) | BDBM50352626
(CHEMBL1822307 | US9796706, Compound 131)Show SMILES FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-c3ncco3)c(=O)ccc2c1 Show InChI InChI=1S/C20H11F3N4O3S/c21-20(22,23)13-2-3-14-11(7-13)1-4-16(29)27(14)9-15(28)26-19-17(12(8-24)10-31-19)18-25-5-6-30-18/h1-7,10H,9H2,(H,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of recombinant JNK3 using ser73 of c-jun as substrate preincubated for 15 mins measured after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 21: 5521-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.100 BindingDB Entry DOI: 10.7270/Q29Z959K |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 9
(Homo sapiens (Human)) | BDBM50352626
(CHEMBL1822307 | US9796706, Compound 131)Show SMILES FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-c3ncco3)c(=O)ccc2c1 Show InChI InChI=1S/C20H11F3N4O3S/c21-20(22,23)13-2-3-14-11(7-13)1-4-16(29)27(14)9-15(28)26-19-17(12(8-24)10-31-19)18-25-5-6-30-18/h1-7,10H,9H2,(H,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of recombinant JNK2 using ser73 of c-jun as substrate preincubated for 15 mins measured after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 21: 5521-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.100 BindingDB Entry DOI: 10.7270/Q29Z959K |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 10
(Homo sapiens (Human)) | BDBM50352626
(CHEMBL1822307 | US9796706, Compound 131)Show SMILES FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-c3ncco3)c(=O)ccc2c1 Show InChI InChI=1S/C20H11F3N4O3S/c21-20(22,23)13-2-3-14-11(7-13)1-4-16(29)27(14)9-15(28)26-19-17(12(8-24)10-31-19)18-25-5-6-30-18/h1-7,10H,9H2,(H,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
IMAGO PHARMACEUTICALS, INC.
US Patent
| Assay Description (1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi... |
US Patent US9796706 (2017)
BindingDB Entry DOI: 10.7270/Q24T6MHK |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 8
(Homo sapiens (Human)) | BDBM50352626
(CHEMBL1822307 | US9796706, Compound 131)Show SMILES FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-c3ncco3)c(=O)ccc2c1 Show InChI InChI=1S/C20H11F3N4O3S/c21-20(22,23)13-2-3-14-11(7-13)1-4-16(29)27(14)9-15(28)26-19-17(12(8-24)10-31-19)18-25-5-6-30-18/h1-7,10H,9H2,(H,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
IMAGO PHARMACEUTICALS, INC.
US Patent
| Assay Description (1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi... |
US Patent US9796706 (2017)
BindingDB Entry DOI: 10.7270/Q24T6MHK |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 9
(Homo sapiens (Human)) | BDBM50352626
(CHEMBL1822307 | US9796706, Compound 131)Show SMILES FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-c3ncco3)c(=O)ccc2c1 Show InChI InChI=1S/C20H11F3N4O3S/c21-20(22,23)13-2-3-14-11(7-13)1-4-16(29)27(14)9-15(28)26-19-17(12(8-24)10-31-19)18-25-5-6-30-18/h1-7,10H,9H2,(H,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
IMAGO PHARMACEUTICALS, INC.
US Patent
| Assay Description (1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi... |
US Patent US9796706 (2017)
BindingDB Entry DOI: 10.7270/Q24T6MHK |
More data for this Ligand-Target Pair | |