Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Stearoyl-CoA desaturase
(Homo sapiens (Human)) | BDBM50424785
(CHEMBL2315102)Show SMILES FC(F)(F)c1ccccc1C(=O)N1CCN(CC1)c1ccc(nn1)C(=O)Nc1ccc(Cl)cc1 Show InChI InChI=1S/C23H19ClF3N5O2/c24-15-5-7-16(8-6-15)28-21(33)19-9-10-20(30-29-19)31-11-13-32(14-12-31)22(34)17-3-1-2-4-18(17)23(25,26)27/h1-10H,11-14H2,(H,28,33) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of SCD1 in human HepG2 cells using [14C]-stearate substrate assessed as decreased production of [14C]-oleic acid after 24 hrs |
J Med Chem 56: 568-83 (2013)
Article DOI: 10.1021/jm301661h BindingDB Entry DOI: 10.7270/Q25Q4XDG |
More data for this Ligand-Target Pair | |
Acyl-CoA desaturase 1
(Mus musculus) | BDBM50424785
(CHEMBL2315102)Show SMILES FC(F)(F)c1ccccc1C(=O)N1CCN(CC1)c1ccc(nn1)C(=O)Nc1ccc(Cl)cc1 Show InChI InChI=1S/C23H19ClF3N5O2/c24-15-5-7-16(8-6-15)28-21(33)19-9-10-20(30-29-19)31-11-13-32(14-12-31)22(34)17-3-1-2-4-18(17)23(25,26)27/h1-10H,11-14H2,(H,28,33) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of SCD1 in ICR mouse liver microsome using [9,10 3H]- stearoyl-Coenzyme A substrate assessed as decreased production of tritiated water af... |
J Med Chem 56: 568-83 (2013)
Article DOI: 10.1021/jm301661h BindingDB Entry DOI: 10.7270/Q25Q4XDG |
More data for this Ligand-Target Pair | |