Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM142741
(US8937095, 3)Show SMILES FC(F)CNC(=O)C#Cc1ccc2\C(=C(\Nc3ccc(CN4CCCC4)cc3)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C31H28F2N4O2/c32-27(33)19-34-28(38)15-11-21-10-14-25-26(18-21)36-31(39)29(25)30(23-6-2-1-3-7-23)35-24-12-8-22(9-13-24)20-37-16-4-5-17-37/h1-3,6-10,12-14,18,27,35H,4-5,16-17,19-20H2,(H,34,38)(H,36,39)/b30-29- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.6 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description The ATP-KM value of the complex is 61 uM. The kinase assays are run in the presence of 100 uM ATP using 10 uM of a substrate peptide. pAUB-IN847 was ... |
US Patent US8937095 (2015)
BindingDB Entry DOI: 10.7270/Q2416VS4 |
More data for this Ligand-Target Pair | |
Aurora kinase B-B
(Xenopus laevis (African clawed frog)) | BDBM142741
(US8937095, 3)Show SMILES FC(F)CNC(=O)C#Cc1ccc2\C(=C(\Nc3ccc(CN4CCCC4)cc3)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C31H28F2N4O2/c32-27(33)19-34-28(38)15-11-21-10-14-25-26(18-21)36-31(39)29(25)30(23-6-2-1-3-7-23)35-24-12-8-22(9-13-24)20-37-16-4-5-17-37/h1-3,6-10,12-14,18,27,35H,4-5,16-17,19-20H2,(H,34,38)(H,36,39)/b30-29- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.6 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description The ATP-KM value of the complex is 61 uM. The kinase assays are run in the presence of 100 uM ATP using 10 uM of a substrate peptide. pAUB-IN847 was ... |
US Patent US8937095 (2015)
BindingDB Entry DOI: 10.7270/Q2416VS4 |
More data for this Ligand-Target Pair | |