Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Endothelial PAS domain-containing protein 1
(Homo sapiens (Human)) | BDBM372997
(US10597366, Compound 98 | US9896418, Compound 98)Show SMILES Fc1cc(Cl)cc(Oc2ccc(c(C#N)c2Br)S(=O)(=O)C(F)(F)F)c1 Show InChI InChI=1S/C14H5BrClF4NO3S/c15-13-10(6-21)12(25(22,23)14(18,19)20)2-1-11(13)24-9-4-7(16)3-8(17)5-9/h1-5H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Peloton Therapeutics, Inc.
US Patent
| Assay Description HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1... |
US Patent US10597366 (2020)
BindingDB Entry DOI: 10.7270/Q2M32ZSW |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor A
(Homo sapiens (Human)) | BDBM372997
(US10597366, Compound 98 | US9896418, Compound 98)Show SMILES Fc1cc(Cl)cc(Oc2ccc(c(C#N)c2Br)S(=O)(=O)C(F)(F)F)c1 Show InChI InChI=1S/C14H5BrClF4NO3S/c15-13-10(6-21)12(25(22,23)14(18,19)20)2-1-11(13)24-9-4-7(16)3-8(17)5-9/h1-5H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.58E+3 | n/a | n/a | n/a | n/a |
Peloton Therapeutics, Inc.
US Patent
| Assay Description VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a... |
US Patent US10597366 (2020)
BindingDB Entry DOI: 10.7270/Q2M32ZSW |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor A
(Homo sapiens (Human)) | BDBM372997
(US10597366, Compound 98 | US9896418, Compound 98)Show SMILES Fc1cc(Cl)cc(Oc2ccc(c(C#N)c2Br)S(=O)(=O)C(F)(F)F)c1 Show InChI InChI=1S/C14H5BrClF4NO3S/c15-13-10(6-21)12(25(22,23)14(18,19)20)2-1-11(13)24-9-4-7(16)3-8(17)5-9/h1-5H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.58E+3 | n/a | n/a | n/a | n/a |
Research Triangle Institute
| Assay Description Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad... |
J Med Chem 50: 3686-95 (2007)
BindingDB Entry DOI: 10.7270/Q2QC05TR |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor A
(Homo sapiens (Human)) | BDBM372997
(US10597366, Compound 98 | US9896418, Compound 98)Show SMILES Fc1cc(Cl)cc(Oc2ccc(c(C#N)c2Br)S(=O)(=O)C(F)(F)F)c1 Show InChI InChI=1S/C14H5BrClF4NO3S/c15-13-10(6-21)12(25(22,23)14(18,19)20)2-1-11(13)24-9-4-7(16)3-8(17)5-9/h1-5H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.58E+3 | n/a | n/a | n/a | n/a |
The Scripps Research Institute
| Assay Description About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-... |
J Med Chem 50: 3359-68 (2007)
BindingDB Entry DOI: 10.7270/Q2FN18HM |
More data for this Ligand-Target Pair | |