Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50121167
(5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclopentane...)Show InChI InChI=1S/C19H15FN2O/c20-15-8-12(11-21)7-14(9-15)13-3-4-17-16(10-13)19(18(23)22-17)5-1-2-6-19/h3-4,7-10H,1-2,5-6H2,(H,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50121167
(5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclopentane...)Show InChI InChI=1S/C19H15FN2O/c20-15-8-12(11-21)7-14(9-15)13-3-4-17-16(10-13)19(18(23)22-17)5-1-2-6-19/h3-4,7-10H,1-2,5-6H2,(H,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin... |
Bioorg Med Chem Lett 12: 3487-90 (2002)
BindingDB Entry DOI: 10.7270/Q2R210RC |
More data for this Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50121167
(5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclopentane...)Show InChI InChI=1S/C19H15FN2O/c20-15-8-12(11-21)7-14(9-15)13-3-4-17-16(10-13)19(18(23)22-17)5-1-2-6-19/h3-4,7-10H,1-2,5-6H2,(H,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of 3 nM [3H]-R5020 binding to progesterone receptor of human T47D cell cytosol |
Bioorg Med Chem Lett 12: 3487-90 (2002)
BindingDB Entry DOI: 10.7270/Q2R210RC |
More data for this Ligand-Target Pair | |