Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cathepsin K
(Homo sapiens (Human)) | BDBM50114027
(CHEMBL3605414)Show SMILES Fc1cc(ccc1NC(=O)N1CCCCC1)C(=O)NC1(CCCCC1)C(=O)NCC#N Show InChI InChI=1S/C22H28FN5O3/c23-17-15-16(7-8-18(17)26-21(31)28-13-5-2-6-14-28)19(29)27-22(9-3-1-4-10-22)20(30)25-12-11-24/h7-8,15H,1-6,9-10,12-14H2,(H,25,30)(H,26,31)(H,27,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Chemistry
Curated by ChEMBL
| Assay Description
Inhibition of human cathepsin-K using Z-Gly-Pro-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay |
J Med Chem 58: 6928-37 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00746
BindingDB Entry DOI: 10.7270/Q2BK1F44 |
More data for this
Ligand-Target Pair | |
Cathepsin S
(Homo sapiens (Human)) | BDBM50114027
(CHEMBL3605414)Show SMILES Fc1cc(ccc1NC(=O)N1CCCCC1)C(=O)NC1(CCCCC1)C(=O)NCC#N Show InChI InChI=1S/C22H28FN5O3/c23-17-15-16(7-8-18(17)26-21(31)28-13-5-2-6-14-28)19(29)27-22(9-3-1-4-10-22)20(30)25-12-11-24/h7-8,15H,1-6,9-10,12-14H2,(H,25,30)(H,26,31)(H,27,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Chemistry
Curated by ChEMBL
| Assay Description
Inhibition of human cathepsin-S using Z-Phe-Val-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay |
J Med Chem 58: 6928-37 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00746
BindingDB Entry DOI: 10.7270/Q2BK1F44 |
More data for this
Ligand-Target Pair | |